Next Article in Journal
Prevalence of Musculoskeletal Injuries, Pain, and Illnesses in Elite Female Basketball Players
Previous Article in Journal
Tissue Oxygen Saturation Change on Upper Extremities After Ultrasound-Guided Infraclavicular Brachial Plexus Blockade; Prospective Observational Study
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle

An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease

1
Department of Physiology, Medical Faculty, Harran University, 63000 Sanliurfa, Turkey
2
Department of Endocrinology, Medical Faculty, Harran University, 63000 Sanliurfa, Turkey
3
Department of Clinical Biochemistry, Medical Faculty, Yıldırım Beyazıt University, 06010 Ankara, Turkey
4
Department of Medicinal Biochemistry, Medical Faculty, Harran University, 63000 Sanliurfa, Turkey
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(6), 275; https://doi.org/10.3390/medicina55060275
Received: 7 March 2019 / Revised: 31 May 2019 / Accepted: 6 June 2019 / Published: 14 June 2019
  |  
PDF [2062 KB, uploaded 14 June 2019]
  |  

Abstract

Background and objectives: The aim of this study was to research oxidative stress and thiol/disulphide homeostasis in Graves’ patients. Materials and Methods: The study included 33 Graves’ patients (research group) and 35 healthy subjects (control group). Serum oxidative stress and thiol/disulphide homeostasis (a new and automated spectrophotometric method developed by Erel and Neselioglu) parameters were studied and compared between the groups. Results: The native and total thiol levels and the native thiol/total thiol ratio were lower in patients with Graves’ disease compared to the control group (p < 0.001, p < 0.001, and p = 0.006, respectively). TOS (total antioxidant status), PC (protein carbonyl), OSI (Oxidative stress index), and disulphide/native thiol and disulphide/total thiol ratios were determined to be higher in the Graves’ disease group than in the control group (p < 0.001, p = 0.001, p = 0.001, p = 0.004, and p = 0.006, respectively). In the Graves’ disease group, the free triiodothyronine (FT3) and free thyroxine (FT4) levels were significantly positively correlated with impaired thiol/disulphide homeostasis and oxidative stress parameters (p < 0.05). Conclusion: The results of the current study demonstrated that oxidative stress and thiol/disulphide homeostasis increased towards disulphide formation due to thiol oxidation in Graves’ disease. In addition, a positive correlation of FT3 and FT4 was observed with oxidative stress parameters and impaired thiol/disulphide homeostasis. View Full-Text
Keywords: Graves’ disease; thiol/disulphide homeostasis; oxidative stress Graves’ disease; thiol/disulphide homeostasis; oxidative stress
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Agan, V.; Celik, H.; Eren, M.A.; Agan, F.Z.; Erel, O.; Neselioglu, S.; Koyuncu, I.; Gonel, A. An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease. Medicina 2019, 55, 275.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Medicina EISSN 1010-660X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top