An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease
AbstractBackground and objectives: The aim of this study was to research oxidative stress and thiol/disulphide homeostasis in Graves’ patients. Materials and Methods: The study included 33 Graves’ patients (research group) and 35 healthy subjects (control group). Serum oxidative stress and thiol/disulphide homeostasis (a new and automated spectrophotometric method developed by Erel and Neselioglu) parameters were studied and compared between the groups. Results: The native and total thiol levels and the native thiol/total thiol ratio were lower in patients with Graves’ disease compared to the control group (p < 0.001, p < 0.001, and p = 0.006, respectively). TOS (total antioxidant status), PC (protein carbonyl), OSI (Oxidative stress index), and disulphide/native thiol and disulphide/total thiol ratios were determined to be higher in the Graves’ disease group than in the control group (p < 0.001, p = 0.001, p = 0.001, p = 0.004, and p = 0.006, respectively). In the Graves’ disease group, the free triiodothyronine (FT3) and free thyroxine (FT4) levels were significantly positively correlated with impaired thiol/disulphide homeostasis and oxidative stress parameters (p < 0.05). Conclusion: The results of the current study demonstrated that oxidative stress and thiol/disulphide homeostasis increased towards disulphide formation due to thiol oxidation in Graves’ disease. In addition, a positive correlation of FT3 and FT4 was observed with oxidative stress parameters and impaired thiol/disulphide homeostasis. View Full-Text
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Agan, V.; Celik, H.; Eren, M.A.; Agan, F.Z.; Erel, O.; Neselioglu, S.; Koyuncu, I.; Gonel, A. An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease. Medicina 2019, 55, 275.
Agan V, Celik H, Eren MA, Agan FZ, Erel O, Neselioglu S, Koyuncu I, Gonel A. An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease. Medicina. 2019; 55(6):275.Chicago/Turabian Style
Agan, Veysel; Celik, Hakim; Eren, Mehmet A.; Agan, Fatma Z.; Erel, Ozcan; Neselioglu, Salim; Koyuncu, Ismail; Gonel, Ataman. 2019. "An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease." Medicina 55, no. 6: 275.
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