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Food Protein-Induced Enterocolitis Syndrome: Proposals for New Definitions

Allergy Unit, Pediatrics Area, Department of Woman and Child Health, Policlinico Gemelli University Foundation IRCCS, Catholic University of Sacre Hearth, 00168 Rome, Italy
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Medicina 2019, 55(6), 216; https://doi.org/10.3390/medicina55060216
Received: 25 February 2019 / Revised: 20 May 2019 / Accepted: 21 May 2019 / Published: 28 May 2019
(This article belongs to the Special Issue Food Allergies)
Acute food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated allergy and is characterized by repetitive profuse vomiting episodes, often in association with pallor, lethargy, and diarrhea, presenting within 1–4 h from the ingestion of a triggering food. In 2017, the international consensus guidelines for the diagnosis and management of FPIES were published. They cover all aspects of this syndrome, which in recent decades has attracted the attention of pediatric allergists. In particular, the consensus proposed innovative diagnostic criteria. However, the diagnosis of acute FPIES is still currently discussed because the interest in this disease is relatively recent and, above all, there are no validated panels of diagnostic criteria. We propose some ideas for reflection on the diagnostic and suspicion criteria of acute FPIES with exemplary stories of children certainly or probably suffering from acute FPIES. For example, we believe that new definitions should be produced for mild forms of FPIES, multiple forms, and those with IgE-mediated symptoms. Moreover, we propose two clinical criteria to suspect acute FPIES and to refer the child to the diagnostic oral food challenge. View Full-Text
Keywords: Diagnostic criteria; food allergy; food protein-induced enterocolitis syndrome; oral food challenge; vomiting Diagnostic criteria; food allergy; food protein-induced enterocolitis syndrome; oral food challenge; vomiting
MDPI and ACS Style

Miceli Sopo, S.; Gelsomino, M.; Rivetti, S.; Del Vescovo, E. Food Protein-Induced Enterocolitis Syndrome: Proposals for New Definitions. Medicina 2019, 55, 216. https://doi.org/10.3390/medicina55060216

AMA Style

Miceli Sopo S, Gelsomino M, Rivetti S, Del Vescovo E. Food Protein-Induced Enterocolitis Syndrome: Proposals for New Definitions. Medicina. 2019; 55(6):216. https://doi.org/10.3390/medicina55060216

Chicago/Turabian Style

Miceli Sopo, Stefano; Gelsomino, Mariannita; Rivetti, Serena; Del Vescovo, Ester. 2019. "Food Protein-Induced Enterocolitis Syndrome: Proposals for New Definitions" Medicina 55, no. 6: 216. https://doi.org/10.3390/medicina55060216

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