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Molecular Targets of Fatty Acid Ethanolamides in Asthma

Vladivostok Branch of Federal State Budgetary Science Institution, Far Eastern Scientific Center of Physiology and Pathology of Respiration—Institute of Medical Climatology and Rehabilitative Treatment, Russkaya st. 73g, 690105 Vladivostok, Russia
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Medicina 2019, 55(4), 87; https://doi.org/10.3390/medicina55040087
Received: 5 February 2019 / Revised: 13 February 2019 / Accepted: 27 March 2019 / Published: 1 April 2019
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Abstract

Asthma is a common allergic pathology of the respiratory tract that requires the study of mechanisms underlying it, due to severe forms of the disease, which are refractory to therapy. The review is devoted to the search for molecular targets of fatty acid ethanolamides in asthma, in particular palmitoylethanolamide (PEA), which has been successfully used in the treatment of chronic inflammatory and neurodegenerative diseases, in the pathogenesis of which the nervous and immune systems are involved. Recently, the potentially important role of neuro-immune interactions in the development of allergic reactions has been established. Many of the clinical symptoms accompanying allergic airway inflammation are the result of the activation of neurons in the airways, so the attention of researchers is currently focused on neuro-immune interactions, which can play an important role in asthma pathophysiology. A growing number of scientific works confirm that the key molecule in the implementation of these inter-systemic interactions is nerve growth factor (NGF). In addition to its classic role in nervous system physiology, NGF is considered as an important factor associated with the pathogenesis of allergic diseases, particularly asthma, by regulating of mast cell differentiation. In this regard, NGF can be one of the targets of PEA in asthma therapy. PEA has a biological effect on the nervous system, and affects the activation and the degranulation of mast cells. View Full-Text
Keywords: fatty acid metabolism; palmitoylethanolamide; immunology; neurons; lung; inflammation; nerve growth factor fatty acid metabolism; palmitoylethanolamide; immunology; neurons; lung; inflammation; nerve growth factor
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Kytikova, O.; Novgorodtseva, T.; Antonyuk, M.; Denisenko, Y.; Gvozdenko, T. Molecular Targets of Fatty Acid Ethanolamides in Asthma. Medicina 2019, 55, 87.

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