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Open AccessReview

IL33/ST2 Axis in Diabetic Kidney Disease: A Literature Review

National Research Council of Italy, Institute of Clinical Physiology (CNR-IFC), Via Moruzzi 1, 56124 Pisa, Italy
School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, Italy
Author to whom correspondence should be addressed.
Medicina 2019, 55(2), 50;
Received: 10 December 2018 / Revised: 11 February 2019 / Accepted: 12 February 2019 / Published: 14 February 2019
(This article belongs to the Special Issue Carbohydrate and Insulin Metabolism in Chronic Kidney Disease)
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Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions. The IL-33/ST2 axis plays an important role in several acute and chronic inflammatory diseases, including asthma and rheumatoid arthritis. Different disorders are related to the activity of IL-33, ST2, or their axis, including cardiovascular disease or renal disturbances. Therefore, in the present work, a literature review was conducted, covering the period from 1 January 2000 to 30 November 2018, in PubMed, ScienceDirect, and Google Scholar database, to assess the involvement of the IL-33/ST2 axis in diabetic kidney disease. 6 articles directly dealing with the argument were identified, highlighting a clear link between IL-33/ST2 axis and diabetic kidney disease or related nephropathy. Overall, the involvement of ST2 seems to be more predictive than IL-33, especially in investigating the deterioration of kidney function; however, both compounds are pivotal in the field of renal diseases. Future studies are required to confirm the scientific evidences on larger and more heterogeneous cohorts. View Full-Text
Keywords: alarmin; chronic kidney disease; diabetes mellitus; IL-33; renal disease; ST2 alarmin; chronic kidney disease; diabetes mellitus; IL-33; renal disease; ST2

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Tonacci, A.; Quattrocchi, P.; Gangemi, S. IL33/ST2 Axis in Diabetic Kidney Disease: A Literature Review. Medicina 2019, 55, 50.

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