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Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran

1
Clinical Immunology Research Center, Ali-ebne Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan 9816743111, Iran
2
Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743111, Iran
3
Department of Neurology, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743111, Iran
4
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad 91388 13944, Iran
5
School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
6
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
7
Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743111, Iran
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(2), 47; https://doi.org/10.3390/medicina55020047
Received: 28 October 2018 / Revised: 4 February 2019 / Accepted: 4 February 2019 / Published: 13 February 2019
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Abstract

Background and Objective: Evidence indicates that genetic factors may be involved in the risk of ischemic stroke (IS). The aim of this study was to assess the effect of genetic polymorphisms located in exons or untranslated regions of MTHFR as well as FV genes on ischemic stroke. Materials and Methods: In this case-control study, 106 patients with IS and 157 healthy volunteers (age <50 years) were genotyped for MTHFR C677T, A1298C, C2572A and C4869G, FVL, and prothrombin G20210A polymorphisms. Results: The MTHFR 677CT genotype was more frequent in patients and increased risk of IS with Odds Ratio = 1.9. The MTHFR A1298C and C2572A polymorphisms were not associated with IS in dominant and recessive models. Our findings showed a significant decrease in the MTHFR 4869CG genotype in IS patients, and this variant was associated with a decreased risk of IS in the dominant model. The CAAT haplotype was associated with increased risk, and the GAAC haplotype was associated with decreased risk of IS compared to other haplotypes. There was no relation between FVL G1691A polymorphism and IS risk. Conclusions: The present study showed that the MTHFR 677CT genotype was more frequent and the MTHFR 4869CG genotype was less frequent in young IS patients. View Full-Text
Keywords: ischemic stroke; Factor V; MTHFR; prothrombin; polymorphism ischemic stroke; Factor V; MTHFR; prothrombin; polymorphism
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Hashemi, S.M.; Ramroodi, N.; Amiri Fard, H.; Talebian, S.; Haghighi Rohani, M.; Rezaei, M.; Noora, M.; Salimi, S. Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran. Medicina 2019, 55, 47.

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