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Open AccessArticle

Migraine without Aura and Subclinical Atherosclerosis in Young Females: Is Gut Microbiota to Blame?

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Department of Internal Medicine,“Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
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Department of Cardiology,“Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
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Department of Neurology,“Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
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Authors to whom correspondence should be addressed.
Medicina 2019, 55(12), 786; https://doi.org/10.3390/medicina55120786
Received: 16 October 2019 / Revised: 11 December 2019 / Accepted: 12 December 2019 / Published: 16 December 2019
Background and Objectives: Migraine with aura (MA) could be considered a risk factor for developing atherosclerosis and cardio-vascular events. However, less is known about the relation between migraine without aura (MWA) and atherosclerosis. Our study aimed to assess whether young female migraineurs, with alterations of gut microbiota could associate early atherosclerosis. Materials and Methods: We conducted an exploratory cross-sectional, pilot study concerning 105 consecutive young females having MWA, with recent normal brain scans, that were free of cardio-vascular risk factors, non-smokers, not on oral contraception, not pregnant, and without thyroid or parathyroid diseases, chronic organ failure, cancer, or on probiotic or antibiotic treatment. Consecutive to assessment of gut microbiota, patients were assigned to two groups: dysbiosis positive (n = 45) and dysbiosis negative (n = 60). All study participants underwent clinical examinations with an assessment of migraine severity, body mass index and carotid intima-media thickness (CIMT), as well as laboratory workups. Statistical analysis was performed using a chi-squared test (χ2), a two-tailed t-test and a nonparametric Spearman’s correlation test. Results: The dysbiosis positive migraineurs showed a significant increase in CIMT along with several anthropometrical, biological and clinical particularities. Significant positive correlations between dysbiosis and CIMT, glycosylated hemoglobin, migraine severity and duration, tumor necrosis factor-alpha, and body mass index were found. Conclusions: Young female migraineurs with significant alterations of gut microbiota experienced early signs of atherosclerosis and displayed severe migraine disability, as well as multiple biological and clinical particularities. View Full-Text
Keywords: young female migraineurs; subclinical atherosclerosis; gut microbiota young female migraineurs; subclinical atherosclerosis; gut microbiota
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Georgescu, D.; Iurciuc, M.S.; Ionita, I.; Dragan, S.; Muntean, M.; Ancusa, O.E.; Reisz, D.; Ionita, M.; Lighezan, D. Migraine without Aura and Subclinical Atherosclerosis in Young Females: Is Gut Microbiota to Blame? Medicina 2019, 55, 786.

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