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Open AccessArticle

Nanomedicine: Insights from a Bibliometrics-Based Analysis of Emerging Publishing and Research Trends

Department of Mathematics and Statistics, York University, Toronto, ON M3J 1P3, Canada
Medicina 2019, 55(12), 785; https://doi.org/10.3390/medicina55120785
Received: 20 November 2019 / Revised: 11 December 2019 / Accepted: 13 December 2019 / Published: 15 December 2019
(This article belongs to the Special Issue Nano-Biosciences in the Field of Health-Care)
Background and Objectives: Nanomedicine, a term coined by the American engineer Eric Drexler (1955) and Robert Freitas Jr. (1952) in the nineties, can be defined as a complex, multi-disciplinary branch of medicine, in which nano-technologies, molecular biotechnologies, and other nano-sciences are applied at every step of disease management, from diagnosis (nano-diagnostics) to treatment (nano-therapeutics), prognosis, and monitoring of biological parameters and biomarkers. Nanomedicine is a relatively young discipline, which is increasingly and exponentially growing, characterized by emerging ethical issues and implications. Nanomedicine has branched out in hundreds of different sub-fields. Materials and Methods: A bibliometrics-based analysis was applied mining the entire content of PubMed/MEDLINE, using “nanomedicine” as a Medical Subject Heading (MeSH) search term. Results: A sample of 6696 articles were extracted from PubMed/MEDLINE and analyzed. Articles had been published in the period from 2003 to 2019, showing an increasing trend throughout the time. Six thematic clusters emerged (first cluster: molecular methods; second cluster: molecular biology and nano-characterization; third cluster: nano-diagnostics and nano-theranostics; fourth cluster: clinical applications, in the sub-fields of nano-oncology, nano-immunology and nano-vaccinology; fifth cluster: clinical applications, in the sub-fields of nano-oncology and nano-infectiology; and sixth cluster: nanodrugs). The countries with the highest percentages of articles in the field of nanomedicine were the North America (38.3%) and Europe (35.1%). Conclusions: The present study showed that there is an increasing trend in publishing and performing research in the super-specialty of nanomedicine. Most productive countries were the USA and European countries, with China as an emerging region. Hot topics in the last years were nano-diagnostics and nano-theranostics and clinical applications in the sub-fields of nano-oncology and nano-infectiology. View Full-Text
Keywords: nanomedicine; bibliometrics; scientometrics nanomedicine; bibliometrics; scientometrics
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Bragazzi, N.L. Nanomedicine: Insights from a Bibliometrics-Based Analysis of Emerging Publishing and Research Trends. Medicina 2019, 55, 785.

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