Cytomegalovirus Seropositivity and Suicidal Behavior: A Mini-Review
by
Marco Paolini 1, David Lester 2
, Michael Hawkins 3, Ameth Hawkins-Villarreal 4,5,†, Denise Erbuto 6, Andrea Fiorillo 7 and Maurizio Pompili 6,*
Marco Paolini 1, David Lester 2, Michael Hawkins 3, Ameth Hawkins-Villarreal 4,5,†, Denise Erbuto 6, Andrea Fiorillo 7 and Maurizio Pompili 6,*
1
Psychiatry Residency Training Program, Faculty of Medicine and Psychology, Sapienza University of Rome, 00185 Rome, Italy
2
Psychology Program, Stockton University, Galloway, NJ 08205, USA
3
Department of Psychiatry, University of Toronto, Toronto, ON M5S, Canada
4
Fetal Medicine Research Center, BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine, University of Barcelona, 08028 Barcelona, Spain
5
Fetal Medicine Service, Obstetrics Department, “Saint Thomas” Hospital, University of Panama, Panama City 0843, Panama
6
Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, 00185 Rome, Italy
7
Department of Psychiatry, University of Campania Luigi Vanvitelli, 80138 Naples, Italy
*
Author to whom correspondence should be addressed.
†
On behalf of the Iberoamerican Research Network in Translational, Molecular and Maternal Fetal Medicine.
Medicina 2019, 55(12), 782; https://doi.org/10.3390/medicina55120782
Received: 6 October 2019 / Revised: 7 December 2019 / Accepted: 9 December 2019 / Published: 12 December 2019
(This article belongs to the Special Issue Preventing Suicide in Patients with Mental Disorders)
Background and objectives: In recent years, a growing body of research has focused on identifying possible biological markers for suicidal behavior, including infective and immunological markers. In this paper, our aim was to review available evidence concerning the association between cytomegalovirus (CMV) infection and suicide. Materials and Methods: A systematic search according to the PRISMA statement was performed on Pubmed. After the screening procedure, we identified five relevant papers. Results: We found inconsistent evidence linking CMV infection and suicide, with some papers reporting an association between CMV seropositivity and suicidal behavior, and others not finding the association. Conclusions: With the evidence available presently, it is not possible to infer whether there is a correlation between suicide and CMV infection.
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Keywords:
suicide; CMV; cytomegalovirus; biomarker; antibodies; review
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MDPI and ACS Style
Paolini, M.; Lester, D.; Hawkins, M.; Hawkins-Villarreal, A.; Erbuto, D.; Fiorillo, A.; Pompili, M. Cytomegalovirus Seropositivity and Suicidal Behavior: A Mini-Review. Medicina 2019, 55, 782.
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