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Open AccessArticle

Single-Center Study of Lymphoepithelioma-Like Carcinoma of Uterine Cervix over a 10-Year Period

1
Department of Gynecologic Oncology, Medical University Pleven, 5800 Pleven, Bulgaria
2
Department of Surgical Oncology, Medical University Pleven, 5800 Pleven, Bulgaria
3
Department of Epidemiology, Medical University Pleven, 5800 Pleven, Bulgaria
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Complex Oncological Center Burgas, 8000 Burgas, Bulgaria
5
EXTRO-Lab, Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, 6020 Innsbruck, Austria
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Tyrolean Cancer Research Institute, 6020 Innsbruck, Austria
7
EORTC Pathobiology Group, 1200 Brussels, Belgium
8
Department of Plastic and Reconstructive Surgery, MU-Pleven, 5800 Pleven, Bulgaria
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(12), 780; https://doi.org/10.3390/medicina55120780
Received: 27 October 2019 / Revised: 2 December 2019 / Accepted: 5 December 2019 / Published: 9 December 2019
(This article belongs to the Section Obstetrics and Gynecology)
Background and objectives: Lymphoepithelioma-like carcinoma (LELC) is a histological type of malignant tumor arising from the uncontrolled mitosis of transformed cells originating in epithelial tissue. It is a rare subtype of squamous cell carcinoma of the uterine cervix. There are significant differences in frequency, mean age, viral status, and outcomes in Asian or Caucasian patients. Materials and Methods: A retrospective study of all cases of lymphoepithelioma-like carcinoma of the cervix at the Clinic of Oncogynecology, University Hospital, Pleven, Bulgaria between 1 January 2007 and 31 December 2016 was performed. All patients were followed-up till March 2019. We analyzed some clinical characteristics of the patients, calculated the frequency of lymphoepithelioma-like carcinoma of the cervix from all patients with stage I cervical cancer, and looked at the overall survival rate, the 5-year survival rate, and the correlation between overall survival, lymph node status, and the size of the tumor. Results: The frequency of lymphoepithelioma-like carcinoma was 3.3% for all cases with cervical carcinoma at stage I. The mean age of the patients with LELC was 49.6 years (range 32–67). Fourteen patients (82.4%) were in the FIGO IB1 stage, three patients (17.6%) were in the FIGO IB2 stage. Lymph nodes were metastatic in three patients (17.6%), non-metastatic in 13 patients (76.5%), and unknown in one patient. The overall survival rate was 76.47% for the study period and the 5-year survival rate of the patients that were followed-up until the 5th year (14 patients) was 69.23%. Conclusions: Lymphoepithelioma-like carcinoma is a rare SCC subtype, but it could be more frequent among western patients than previously thought. Our results do not confirm the data showing low risk of lymph metastasis and good prognosis of LELC, which is why we think that the treatment in these cases has to be more aggressive than is reported in the literature. View Full-Text
Keywords: lymphoepithelioma-like cervical cancer; overall survival rate; lymph node involvement; prognosis; follow-up lymphoepithelioma-like cervical cancer; overall survival rate; lymph node involvement; prognosis; follow-up
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Yordanov, A.; Karamanliev, M.; Karcheva, M.; Konsoulova, A.; Vasileva-Slaveva, M.; Strashilov, S. Single-Center Study of Lymphoepithelioma-Like Carcinoma of Uterine Cervix over a 10-Year Period. Medicina 2019, 55, 780.

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