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Indexes of Angiogenic Activation in Myocardial Samples of Patients with Advanced Chronic Heart Failure

Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy
Pulmonary Rehabilitation Unit and Laboratory of Cytoimmunopathology of the Heart and Lung, Istituti Clinici Scientifici Maugeri, 28010 Veruno, Italy
Department of Clinical and Biological Sciences, University of Torino, San Luigi Hospital, 10043 Turin, Italy
Department of Cardiovascular and Thoracic Surgery, University of Turin, 10126 Turin, Italy
Division of Cardiology, Istituti Clinici Scientifici Maugeri, 28010 Veruno, Italy
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Medicina 2019, 55(12), 766;
Received: 4 October 2019 / Revised: 26 November 2019 / Accepted: 26 November 2019 / Published: 29 November 2019
Background and objectives: Ischemic and idiopathic heart failure are characterized by reactive cardiac fibrosis and impaired vasculogenesis involving pro-angiogenic factors such as angiogenin, angiopoietin-1 (Ang-1), and angiopoietin-2 (Ang-2), as demonstrated in experimental models of heart failure. However, differences in the molecular pathways between these cardiomyopathies are still unclear. In this short communication, we evaluate and compare the expression of pro-angiogenic molecules in the heart tissue of patients with advanced chronic heart failure (CHF) of ischemic vs. nonischemic etiology. Materials and Methods: We obtained heart tissue at transplantation from left ventricular walls of 16 explanted native hearts affected by either ischemic (ICM) or nonischemic dilated cardiomyopathy (NIDCM). Tissue samples were examined using immunohistochemistry for angiogenic molecules. Results: We found immunopositivity (I-pos) for angiopoietin-1 mainly in the cardiomyocytes, while we observed I-pos for Ang-2 and Tie-2 receptor mainly in endothelial cells. Expression of Procollagen-I (PICP), angiogenin, Ang-1, and Tie-2 receptor was similar in ICM and NIDCM. In contrast, endothelial immunopositivity for Ang-2 was higher in ICM samples than NIDCM (p = 0.03). Conclusions: In our series of CHF heart samples, distribution of Ang-1 and angiogenin was higher in cardiomyocytes while that of Ang-2 was higher in endothelial cells; moreover, Ang-2 expression was higher in ICS than NIDCM. Despite the small series examined, these findings suggest different patterns of angiogenic stimulation in ICM and NIDCM, or at least a more altered endothelial integrity in ICD. Our data may contribute to a better understanding of the angiogenesis signaling pathways in CHF. Further studies should investigate differences in the biochemical processes leading to heart failure. View Full-Text
Keywords: heart failure; angiogenesis; angiopoietin-1; angiopoietin-2; cardiac fibrosis heart failure; angiogenesis; angiopoietin-1; angiopoietin-2; cardiac fibrosis
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Komici, K.; Gnemmi, I.; Sangiorgi, C.; Ricciardolo, F.L.M.; Rinaldi, M.; Di Stefano, A.; Eleuteri, E. Indexes of Angiogenic Activation in Myocardial Samples of Patients with Advanced Chronic Heart Failure. Medicina 2019, 55, 766.

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