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Open AccessArticle

TZAP Mutation Leads to Poor Prognosis of Patients with Breast Cancer

1
Department of Anatomy, School of Medicine, Keimyung University, Daegu 42601, Korea
2
Department of Surgery, School of Medicine, Keimyung University, Dongsan Medical Center, Daegu 42601, Korea
3
Department of Pathology, School of Medicine, Keimyung University, Dongsan Medical Center, Daegu 42601, Korea
*
Authors to whom correspondence should be addressed.
This article was previously presented on the Breast Cancer Symposium in San Antonio, Texas, USA, on 4–8 Dec. 2018.
These authors contributed equally to this work.
Medicina 2019, 55(11), 748; https://doi.org/10.3390/medicina55110748
Received: 1 October 2019 / Revised: 5 November 2019 / Accepted: 8 November 2019 / Published: 18 November 2019
Background and Objectives: ZBTB48 is a telomere-associated factor that has been renamed as telomeric zinc finger-associated protein (TZAP). It binds preferentially to long telomeres, competing with telomeric repeat factors 1 and 2. Materials and Methods: We analyzed the TZAP mutation in 128 breast carcinomas (BCs). In addition, its association with telomere length was investigated. Results: The TZAP mutation (c.1272 G > A, L424L) was found in 7.8% (10/128) of the BCs and was associated with the N0 stage. BCs with the TZAP mutation had longer telomeres than those without this mutation. Survival analysis showed that the TZAP mutation resulted in poorer overall survival. Conclusions: These results suggest that the TZAP mutation is a possible prognostic marker in BC. View Full-Text
Keywords: TZAP; telomere; breast carcinoma; ZBTB48 TZAP; telomere; breast carcinoma; ZBTB48
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Heo, Y.-R.; Lee, M.-H.; Kwon, S.-Y.; Cho, J.; Lee, J.-H. TZAP Mutation Leads to Poor Prognosis of Patients with Breast Cancer . Medicina 2019, 55, 748.

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