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Open AccessFeature PaperArticle

Maternal Blood Concentration of Tadalafil and Uterine Blood Flow in Pregnancy

1
Department of Obstetrics and Gynecology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan
2
Department of Clinical Pharmacy and Biopharmaceutics, Mie University Hospital, 2-174 Edobashi, Tsu, Mie 514-8507, Japan
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(10), 708; https://doi.org/10.3390/medicina55100708
Received: 27 August 2019 / Revised: 14 October 2019 / Accepted: 16 October 2019 / Published: 21 October 2019
(This article belongs to the Section Obstetrics and Gynecology)
Background and Objectives: Tadalafil for treatment of fetal growth restriction (FGR) or preeclampsia is given once a day orally. The drug kinetics of tadalafil were investigated to determine the ideal dosage to promote uterine blood flow. Materials and Methods: We recruited five pregnant women with FGR or preeclampsia before administration of tadalafil, all of which were administered tadalafil (20 mg/day, once-daily dosing). The blood concentration of tadalafil was measured 1, 2, 4, 6, 8, and 24 h after administration, and uterine blood flow was measured before tadalafil administration and 2–4 and 20–24 h after. We then analyzed the correlation between tadalafil blood concentration and uterine artery blood flow. Results: The blood concentration of tadalafil correlated with uterine artery blood flow in pregnant women. The blood concentration of tadalafil and uterine artery blood flow decreased 5 h after administration of tadalafil. Conclusions: The blood concentration of tadalafil and uterine artery blood flow fluctuate in parallel, the latter was decreased by reduced blood concentration. Thus, a study of tadalafil administered twice a day in pregnant women will be needed to stabilize uterine artery blood flow. View Full-Text
Keywords: tadalafil; pregnancy; preeclampsia; fetal growth restriction tadalafil; pregnancy; preeclampsia; fetal growth restriction
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Tanaka, H.; Maki, S.; Magawa, S.; Nii, M.; Tanaka, K.; Ikemura, K.; Toriyabe, K.; Ikeda, T. Maternal Blood Concentration of Tadalafil and Uterine Blood Flow in Pregnancy. Medicina 2019, 55, 708.

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