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Daily Heart Rate Variability Indices in Subjects with and Without Metabolic Syndrome Before and After the Elimination of the Influence of Day-time Physical Activity

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State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, Lithuania
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InMedica, LT-08406 Vilnius, Lithuania
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Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania
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Centre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, LT-08661 Vilnius, Lithuania
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Kaunas University of Technology, LT-44249 Kaunas, Lithuania
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Centre of Rehabilitation, Vilnius University Hospital Santaros Klinikos, Physical and Sports Medicine, LT-08661 Vilnius, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(10), 700; https://doi.org/10.3390/medicina55100700
Received: 29 August 2019 / Revised: 9 October 2019 / Accepted: 14 October 2019 / Published: 17 October 2019
Background and Objectives: The available research shows conflicting data on the heart rate variability (HRV) in metabolic syndrome (MetS) subjects. The discrepancy suggests a methodical shortcoming: due to the influence of physical activity, the standard measuring of HRV at rest is not comparable with HRV assessment based on 24 h Holter monitoring, which is preferred because of its comprehensiveness. To obtain a more reliable measure and to clarify to what extent HRV is altered in MetS, we assessed a 24 h HRV before and after the elimination of the influence of physical activity. Materials and Methods: We investigated 69 metabolic syndrome (MetS) and 37 control subjects, aged 50–55. In all subjects, 24 h monitoring of electrocardiogram, blood pressure, and actigraphy profiles were conducted. To eliminate the influence of day-time physical activity on RR intervals (RRI), a linear polynomial autoregressive model with exogenous terms (ARX) was used. Standard spectral RRI analysis was performed. Results: Subjects with MetS had blunted HRV; the diurnal SDNN index was reliably lower in the MetS group than in control subjects. The elimination of the influence of physical activity did not reveal a significant HRV change in long-term indices (SDNN, SDANN, and SD2), whilst adjacent RRI values (RMSSD, pNN50, and SD1) and SDNN index significantly increased (p < 0.001). An increase in the latter indices highlighted the HRV difference between the MetS and control groups; a significant (p < 0.001) decrease of all short-term HRV variables was found in the MetS group (p < 0.01), and low-frequency spectral components were less pronounced in the MetS group. Conclusion: The application of a polynomial autoregressive model in 24 h HRV assessment allowed for the exclusion of the influence of physical activity and revealed that MetS is associated with blunted HRV, which reflects mitigated parasympathetic tone. View Full-Text
Keywords: metabolic syndrome; heart rate variability; physical activity; hypertension metabolic syndrome; heart rate variability; physical activity; hypertension
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Slušnienė, A.; Laucevičius, A.; Navickas, P.; Ryliškytė, L.; Stankus, V.; Stankus, A.; Navickas, R.; Laucevičienė, I.; Kasiulevičius, V. Daily Heart Rate Variability Indices in Subjects with and Without Metabolic Syndrome Before and After the Elimination of the Influence of Day-time Physical Activity. Medicina 2019, 55, 700.

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