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Impact of Pruritus on Sleep Quality of Hemodialysis Patients: A Systematic Review and Meta-Analysis

1
Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan
2
Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences Lahore, Lahore 5400, Pakistan
3
School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(10), 699; https://doi.org/10.3390/medicina55100699
Received: 21 July 2019 / Revised: 25 September 2019 / Accepted: 30 September 2019 / Published: 17 October 2019
Background and objectives: Chronic kidney disease (CKD)-associated pruritus is a common and disturbing condition which has a negative impact on sleep quality, as well as overall health-related quality of life of patients receiving hemodialysis. To date, no systematic review has been undertaken, and there is a lack of concise evidence that statistically quantifies the impact of pruritus based on published data. Materials and Methods: A systematic search was done for original articles published in peer-reviewed English journals from database inception on 20 December, 2018, in the following databases: PubMed, MEDLINE, EMBASE, Ovid, CINHAL, ProQuest, and Scopus. Results: A total of 9217 research articles were identified. After removal of duplicates and screening for titles and abstracts, 28 articles were selected. The prevalence of disturbed sleep was 4–94%, while the pooled proportion on random effect in the study was 40% (95% CI = 0.30 to 0.49); I2 = 99.8%. However, the prevalence of disturbed sleep quality and quantity due to pruritus was 9–76%, and the pooled proportion on random effect in the study was 50% (95% CI = 0.37 to 0.64); I2 = 99.8%. Conclusions: Patients undergoing hemodialysis who are affected by CKD-associated pruritus have a higher chance of experiencing sleep disturbances. The prevalence of disturbed sleep due to CKD-associated pruritus was found to be 9–76% in the included studies for patients receiving hemodialysis therapy. View Full-Text
Keywords: end stage renal disease; hemodialysis; CKD-associated pruritus; sleep; chronic kidney disease; systematic review; meta-analysis end stage renal disease; hemodialysis; CKD-associated pruritus; sleep; chronic kidney disease; systematic review; meta-analysis
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Rehman, I.U.; Chohan, T.A.; Bukhsh, A.; Khan, T.M. Impact of Pruritus on Sleep Quality of Hemodialysis Patients: A Systematic Review and Meta-Analysis. Medicina 2019, 55, 699.

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