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Open AccessArticle

Clinical Significance of Isolates Known to Be Blood Culture Contaminants in Pediatric Patients

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Department of Laboratory Medicine, Chonnam National University Medical School & Hospital, Gwangju 61469, Korea
2
Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
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Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
4
Division of Infectious Diseases and Immunodeficiency, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(10), 696; https://doi.org/10.3390/medicina55100696
Received: 18 July 2019 / Revised: 26 September 2019 / Accepted: 15 October 2019 / Published: 17 October 2019
Background and objectives: The objective of this study was to investigate the clinical significance of isolates from blood stream infection known to be blood culture contaminants in pediatric patients. Materials and Methods: Microbiological reports and medical records of all blood culture tests issued from 2002 to 2012 (n = 76,331) were retrospectively reviewed. Evaluation for potential contaminants were done by reviewing medical records of patients with the following isolates: coagulase-negative Staphylococcus, viridans group Streptococcus, Bacillus, Corynebacterium, Micrococcus, Aerococcus, and Proprionibacterium species. Repeated cultures with same isolates were considered as a single case. Cases were evaluated for their status as a pathogen. Results: Coagulase-negative Staphylococcus had clinical significance in 23.8% of all cases. Its rate of being a true pathogen was particularly high in patients with malignancy (43.7%). Viridans group Streptococcus showed clinical significance in 46.2% of all cases. Its rate of being a true pathogen was similar regardless of the underlying morbidity of the patient. The rate of being a true pathogens for remaining isolates was 27.7% for Bacillus and 19.0% for Corynebacterium species. Conclusions: Coagulase-negative Staphylococcus and viridans group Streptococcus isolates showed high probability of being true pathogens in the pediatric population, especially in patients with underlying malignancy. View Full-Text
Keywords: pediatric bacteremia; blood stream infection; contaminant; viridans group streptococcus; Coagulase-negative Staphylococcus; true infection pediatric bacteremia; blood stream infection; contaminant; viridans group streptococcus; Coagulase-negative Staphylococcus; true infection
MDPI and ACS Style

Chun, S.; Kang, C.-I.; Kim, Y.-J.; Lee, N.Y. Clinical Significance of Isolates Known to Be Blood Culture Contaminants in Pediatric Patients. Medicina 2019, 55, 696.

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