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Effect of Muntingia calabura L. Stem Bark Extracts on Uric Acid Concentration and Renal Histopathology in Diabetic Rats

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Department of Biology Education, Faculty of Teacher Training and Education, Syiah Kuala University Darussalam, Banda Aceh 23111, Indonesia
2
Laboratory of Anatomy, Faculty of Veterinary Medicine, Syiah Kuala University, Darussalam, Banda Aceh 23111, Indonesia, [email protected]
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(10), 695; https://doi.org/10.3390/medicina55100695
Received: 31 July 2019 / Revised: 30 September 2019 / Accepted: 9 October 2019 / Published: 16 October 2019
Background and objectives: This study was designed to determine uric acid concentration and renal histopathology of Muntingia calabura L. stem bark extract in diabetic rats and to compare the natural product of M. calabura L. stem bark extract with allopurinol. Materials and Methods: A completely randomized design was used for the experiment, which consisted of six treatment groups, each consisting of four rats, as follows: 1) NR, normal rat; 2) KN, diabetic rat (negative control); 3) KP, diabetic rats given allopurinol 10 mg/kg body weight; 4) EM150, diabetic rats given the test extract 150 mg/kg body weight/day; 5) EM300, diabetic rats given the test extract 300 mg/kg body weight/day; and 6) EM450, diabetic rats given for extract 450 mg/kg body weight/ day. Results: The results showed that M. calabura L. stem bark extract decreased (p < 0.05) uric acid concentrations in diabetic rats and no specific damage to renal proximal tubular cells was seen. Conclusions: It was concluded that M. calabura L. stem bark extract has a potential as an antihyperuricemic in diabetic rats. The recommended dose was 300 mg/kg body weight to provide a significant effect on reducing the uric acid level in diabetic rats. Our results support the use of this plant for the treatment of degenerative and inflammatory diseases. View Full-Text
Keywords: uric acid levels; aloxan; diabetic rat; Muntingia calabura L. uric acid levels; aloxan; diabetic rat; Muntingia calabura L.
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MDPI and ACS Style

Safrida, S.; Sabri, M. Effect of Muntingia calabura L. Stem Bark Extracts on Uric Acid Concentration and Renal Histopathology in Diabetic Rats. Medicina 2019, 55, 695.

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