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Open AccessArticle

Controlled Release of Metformin Hydrochloride from Core-Shell Nanofibers with Fish Sarcoplasmic Protein

Center for Nanotechnology & Biomaterials Application and Research, Marmara University, 34722 Istanbul, Turkey
Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, 34722 Istanbul, Turkey
Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, 34755 Istanbul, Turkey
Department of Biochemistry, Marmara University, 34854 Istanbul, Turkey
Department of Chemical Engineering, Faculty of Engineering, Marmara University, 34722 Istanbul, Turkey
Department of Textile Engineering, Faculty of Technology, Marmara University 34722 Istanbul, Turkey
Department of Biomedical Devices Technology, Vocational School of Technical Sciences, Istanbul University-Cerrahpasa, 34500 Istanbul, Turkey
Nanortopedi Industry and Trade Inc., Sanayi Mahallesi Teknopark Bulvari, Teknopark Istanbul, 34906 Istanbul, Turkey
Department of Industrial Engineering and Management, “Lucian Blaga” University of Sibiu, Faculty of Engineering, RO-550025 Sibiu, Romania
Academy of Romanian Scientists, 54 Splaiul Independentei, Sector 5, 50085 Bucharest, Romania
Department of Science and Engineering of Oxidic Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 011061 Bucharest, Romania
Authors to whom correspondence should be addressed.
Medicina 2019, 55(10), 682;
Received: 25 August 2019 / Revised: 26 September 2019 / Accepted: 4 October 2019 / Published: 10 October 2019
(This article belongs to the Special Issue Nano-Biosciences in the Field of Health-Care)
Background and Objectives: A coaxial electrospinning technique was used to produce core/shell nanofibers of a polylactic acid (PLA) as a shell and a polyvinyl alcohol (PVA) containing metformin hydrochloride (MH) as a core. Materials and Methods: Fish sarcoplasmic protein (FSP) was extracted from fresh bonito and incorporated into nanofiber at various concentrations to investigate the influence on properties of the coaxial nanofibers. The morphology, chemical structure and thermal properties of the nanofibers were studied. Results: The results show that uniform and bead-free structured nanofibers with diameters ranging from 621 nm to 681 nm were obtained. A differential scanning calorimetry (DSC) analysis shows that FSP had a reducing effect on the crystallinity of the nanofibers. Furthermore, the drug release profile of electrospun fibers was analyzed using the spectrophotometric method. Conclusions: The nanofibers showed prolonged and sustained release and the first order kinetic seems to be more suitable to describe the release. MTT assay suggests that the produced drug and protein loaded coaxial nanofibers are non-toxic and enhance cell attachment. Thus, these results demonstrate that the produced nanofibers had the potential to be used for diabetic wound healing applications. View Full-Text
Keywords: coaxial electrospinning; fish sarcoplasmic protein; nanofibers; wound healing coaxial electrospinning; fish sarcoplasmic protein; nanofibers; wound healing
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Sena, S.; Sumeyra, K.N.; Ulkugul, G.; Sema, A.; Betul, K.; Muge, S.B.; Sayip, E.M.; Muhammet, U.; Cevriye, K.; Mahir, M.; Titu, M.A.; Ficai, D.; Ficai, A.; Gunduz, O. Controlled Release of Metformin Hydrochloride from Core-Shell Nanofibers with Fish Sarcoplasmic Protein. Medicina 2019, 55, 682.

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