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Open AccessReview

Oral Food Challenge

1
Operative Unit of Paediatrics, S. Camillo-Forlanini Hospital, Circonvallazione Gianicolense 87, 00152 Rome, Italy
2
Department of Paediatrics, Sapienza University of Rome, Viale Del Policlinico 155, 00161 Roma, Italy
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(10), 651; https://doi.org/10.3390/medicina55100651
Received: 19 June 2019 / Revised: 15 September 2019 / Accepted: 20 September 2019 / Published: 27 September 2019
(This article belongs to the Special Issue Food Allergies)
Oral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic accuracy and they are not sufficient to make a strict diagnosis of food allergy. Higher concentrations of food-specific IgE or larger allergy prick skin test wheal sizes correlate with an increased likelihood of a reaction upon ingestion. Several cut-off values, to make a diagnosis of some food allergies (e.g., milk, egg, peanut, etc.) without performing an OFC, have been suggested, but their use is still debated. The oral food challenge should be carried out by experienced physicians in a proper environment equipped for emergency, in order to carefully assess symptoms and signs and correctly manage any possible allergic reaction. This review does not intend to analyse comprehensively all the issues related to the diagnosis of food allergies, but to summarize some practical information on the OFC procedure, as reported in a recent issue by The Expert Review of Food Allergy Committee of Italian Society of Pediatric Allergy and Immunology (SIAIP). View Full-Text
Keywords: oral food challenge; food allergy; food allergens; single-blind; placebo-controlled oral food challenge; double-blind; placebo-controlled oral food challenge oral food challenge; food allergy; food allergens; single-blind; placebo-controlled oral food challenge; double-blind; placebo-controlled oral food challenge
MDPI and ACS Style

Calvani, M.; Bianchi, A.; Reginelli, C.; Peresso, M.; Testa, A. Oral Food Challenge. Medicina 2019, 55, 651.

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