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Open AccessCase Report

Pulmonary Embolism and Severe Asthma: Case Report and Literature Review

by Po-Hsin Lee 1 and Pin-Kuei Fu 2,3,4,*
1
Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan
2
Department of Critical Care Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan
3
College of Human Science and Social Innovation, Hungkuang University, Taichung 43302, Taiwan
4
Science College, Tunghai University, Taichung 40704, Taiwan
*
Author to whom correspondence should be addressed.
Medicina 2019, 55(10), 647; https://doi.org/10.3390/medicina55100647
Received: 25 August 2019 / Revised: 24 September 2019 / Accepted: 25 September 2019 / Published: 26 September 2019
Pulmonary embolism is a life-threatening disease. Its development is generally thought to be due to causes collectively known as the Virchow’s triad. Chronic inflammations are associated with the activation of coagulation and increased risks of venous thromboembolic events. Asthma is one of the chronic inflammatory diseases associated with procoagulants and antifibrinolytic activities in the airways. Coagulation is activated in patients with asthma with the following steps of pathophysiology: Increased tissue factor expression in various cell types, decreased activity of the anticoagulant protein C system and inhibition of fibrinolysis through over-production of plasminogen activator inhibitor type 1 (PAI-1). Asthma is therefore likely a risk factor for pulmonary embolism, especially in those patients with severe disease conditions together with frequent exacerbation. Here we present a case of severe asthma associated with coagulopathy and complicated by massive pulmonary embolism, presented with typical S1Q3T3 on electrocardiography (ECG) and massive thrombosis on computed tomography angiography, successfully treated with directed catheter thrombolytic therapy. View Full-Text
Keywords: severe asthma; coagulopathy; massive pulmonary embolism; plasminogen activator inhibitor type I (PAI-1); tissue factor (TF) severe asthma; coagulopathy; massive pulmonary embolism; plasminogen activator inhibitor type I (PAI-1); tissue factor (TF)
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Lee, P.-H.; Fu, P.-K. Pulmonary Embolism and Severe Asthma: Case Report and Literature Review. Medicina 2019, 55, 647.

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