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Tools for the Quality Control of Pharmaceutical Heparin

Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK
Institute for Science and Technology in Medicine, Keele University, Keele, Staffordshire ST5 5BG, UK
School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
Author to whom correspondence should be addressed.
Medicina 2019, 55(10), 636;
Received: 30 June 2019 / Revised: 2 September 2019 / Accepted: 4 September 2019 / Published: 25 September 2019
Heparin is a vital pharmaceutical anticoagulant drug and remains one of the few naturally sourced pharmaceutical agents used clinically. Heparin possesses a structural order with up to four levels of complexity. These levels are subject to change based on the animal or even tissue sources that they are extracted from, while higher levels are believed to be entirely dynamic and a product of their surrounding environments, including bound proteins and associated cations. In 2008, heparin sources were subject to a major contamination with a deadly compound—an over-sulphated chondroitin sulphate polysaccharide—that resulted in excess of 100 deaths within North America alone. In consideration of this, an arsenal of methods to screen for heparin contamination have been applied, based primarily on the detection of over-sulphated chondroitin sulphate. The targeted nature of these screening methods, for this specific contaminant, may leave contamination by other entities poorly protected against, but novel approaches, including library-based chemometric analysis in concert with a variety of spectroscopic methods, could be of great importance in combating future, potential threats. View Full-Text
Keywords: heparin; glycosaminoglycans; spectroscopic methods; chemometrics; quality control; analysis heparin; glycosaminoglycans; spectroscopic methods; chemometrics; quality control; analysis
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Devlin, A.; Mycroft-West, C.; Procter, P.; Cooper, L.; Guimond, S.; Lima, M.; Yates, E.; Skidmore, M. Tools for the Quality Control of Pharmaceutical Heparin. Medicina 2019, 55, 636.

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