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Pediatric Celiac Disease in Central and East Asia: Current Knowledge and Prevalence

Department of Medicine, Nazarbayev University School of Medicine, 010000 Astana, Kazakhstan
Department of Pediatrics, National Research Center of Mother and Child Health, University Medical Center, 010000 Astana, Kazakhstan
Center of Laboratory Medicine, Republican Diagnostic Center, University Medical Center, 010000 Astana, Kazakhstan
Department of Pediatrics, Universita’ Politecnica delle Marche, 60121 Ancona, Italy
Author to whom correspondence should be addressed.
Medicina 2019, 55(1), 11;
Received: 12 December 2018 / Revised: 31 December 2018 / Accepted: 3 January 2019 / Published: 12 January 2019
(This article belongs to the Special Issue Advances in Celiac Disease)
PDF [582 KB, uploaded 12 January 2019]


The current prevalence of pediatric Celiac Disease (CD) is estimated to be around 1% in the general population, worldwide. However, according to the geographic area, a great variability of CD prevalence has been described. Whereas a number of studies are available from Europe, North and South America, Australia, South-West Asia, and North Africa, the knowledge and awareness of CD in large parts of the remaining world areas is definitively poor. In several countries of Central and East Asia, the consumption of wheat is consistent and/or has significantly increased in recent decades, and CD is supposed to be underdiagnosed in children. In this mini-review, we aimed to summarize the current knowledge about the prevalence of pediatric CD in Central and East Asia, paying attention to the HLA-DQ immunogenetic background as well. Indeed, CD is likely not to be as uncommon as previously or currently thought in countries like Russia, Kazakhstan, and China, in addition to India, where pediatric CD has been clearly showed to be quite prevalent. Therefore, there is an urgent need for population-based studies on the prevalence of CD in those countries, especially in children, in order to increase the awareness of this disease and to improve the diagnostic strategy in these areas. View Full-Text
Keywords: celiac disease; children; HLA-DQ; prevalence; Asia celiac disease; children; HLA-DQ; prevalence; Asia

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Poddighe, D.; Rakhimzhanova, M.; Marchenko, Y.; Catassi, C. Pediatric Celiac Disease in Central and East Asia: Current Knowledge and Prevalence. Medicina 2019, 55, 11.

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