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Medicina 2018, 54(6), 108; https://doi.org/10.3390/medicina54060108

The Role of Occupational and Environmental Exposures in the Pathogenesis of Idiopathic Pulmonary Fibrosis: A Narrative Literature Review

1
Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham B95SS, UK
2
Birmingham Regional NHS Occupational Lung Disease Service, Birmingham Chest Clinic, Birmingham B33HX, UK
3
Occupational and Environmental Medicine, Institute of Clinical Sciences, University of Birmingham, Birmingham B152TT, UK
*
Author to whom correspondence should be addressed.
Received: 19 November 2018 / Accepted: 5 December 2018 / Published: 10 December 2018
(This article belongs to the Special Issue Idiopathic Pulmonary Fibrosis Research)
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PDF [312 KB, uploaded 16 December 2018]

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterised by a progressive and irreversible decline in lung function, which is associated with poor long-term survival. The pathogenesis of IPF is incompletely understood. An accumulating body of evidence, obtained over the past three decades, suggests that occupational and environmental exposures may play a role in the development of IPF. This narrative literature review aims to summarise current understanding and the areas of ongoing research into the role of occupational and environmental exposures in the pathogenesis of IPF. View Full-Text
Keywords: idiopathic pulmonary fibrosis; IPF; pathogenesis; occupational; environmental; exposures idiopathic pulmonary fibrosis; IPF; pathogenesis; occupational; environmental; exposures
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Trethewey, S.P.; Walters, G.I. The Role of Occupational and Environmental Exposures in the Pathogenesis of Idiopathic Pulmonary Fibrosis: A Narrative Literature Review. Medicina 2018, 54, 108.

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