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Medicina 2018, 54(6), 101; https://doi.org/10.3390/medicina54060101

Breast Cancer Relapse, Post-Surgical Confusion, and Dementia in the Elderly: An Unexpected Connection but with the Same Proposed Solution

1
Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA 02115, USA, [email protected]
2
Anesthesiology and Perioperative Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 1090 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Received: 17 October 2018 / Revised: 21 November 2018 / Accepted: 21 November 2018 / Published: 3 December 2018
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Abstract

A simple solution may exist for both the problem of sudden dementia and confusion after surgery in the elderly and the bimodal relapse pattern among breast cancer patients who were treated with a mastectomy. Systemic inflammation by a variety of mechanisms can induce tumor outgrowth from dormant states, such as single dormant cells and avascular micrometastases. This may also explain sudden confusion and dementia for the elderly after surgery. We propose that surgery-induced inflammation may be addressed by “protective anesthesia”. We suggest ketorolac for 4 days starting at the time of surgery to prevent early relapse in breast and probably other cancers; perhaps that or something similar could be used before surgery in elderly patients to prevent post-operative cognitive dysfunction. View Full-Text
Keywords: breast cancer relapse; confusion; dementia; inflammation breast cancer relapse; confusion; dementia; inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Retsky, M.W.; Forget, P. Breast Cancer Relapse, Post-Surgical Confusion, and Dementia in the Elderly: An Unexpected Connection but with the Same Proposed Solution. Medicina 2018, 54, 101.

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