Genetic variations of MTHFR gene and their association with preterm birth in Korean women
Materials and methods: The subjects for case–control study were collected a total of 226 Korean women (98 preterm-birth patients and 128 controls). Genotype frequency differences between the case and the control were assessed using chi-square tests. Mann–Whitney t-test was used to estimate the effects of 1298 A/C genotype on clinicopathological characteristics (systolic blood pressure, diastolic blood pressure, birth weight, and gestational age at delivery) in preterm-birth patients.
Results: Our results showed that the MTHFR 677 C/T polymorphism was significantly associated with preterm-birth patients in the analysis of genotype frequency (P = 0.044) and the over-dominant model (OR = 0.54; 95% CI, 0.320–0.920; P = 0.023). The recessive model showed a marginal trend toward significance (OR = 0.47; 95% CI, 0.220–1.010; P = 0.046). The 1298 A/C polymorphism was also associated with reduced preterm-birth risk in the recessive model (P = 0.032). In the correlation analysis, the 1298 C allele was significantly associated with increasing of gestational age at delivery in preterm-birth patients (P = 0.034).
Conclusions: Our findings suggested that the MTHFR gene 677 C/T and 1298 A/C polymorphisms might have protective effects for preterm birth in the Korean women.
Wook Hwang, I.; Dan Kang, Y.; Na Kwon, B.; Ho Hong, J.; Hun Han, S.; Soo Kim, J.; Wan Park, J.; Jun Jin, H. Genetic variations of MTHFR gene and their association with preterm birth in Korean women. Medicina 2017, 53, 380-385.
Wook Hwang I, Dan Kang Y, Na Kwon B, Ho Hong J, Hun Han S, Soo Kim J, Wan Park J, Jun Jin H. Genetic variations of MTHFR gene and their association with preterm birth in Korean women. Medicina. 2017; 53(6):380-385.Chicago/Turabian Style
Wook Hwang, In; Dan Kang, Yun; Na Kwon, Bit; Ho Hong, Jun; Hun Han, Seung; Soo Kim, Jong; Wan Park, Jin; Jun Jin, Han. 2017. "Genetic variations of MTHFR gene and their association with preterm birth in Korean women." Medicina 53, no. 6: 380-385.