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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
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Medicina 2017, 53(5), 316-322; (registering DOI)

Rat spinal ganglia in assessment of protective action of antioxidants: A morphological study

Department of Histology and Embryology, Bogomolets National Medical University, Kyiv, Ukraine
Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
Author to whom correspondence should be addressed.
Received: 30 January 2017 / Revised: 7 November 2017 / Accepted: 21 November 2017 / Published: 29 November 2017
PDF [3508 KB, uploaded 27 February 2018]


Background and objective: Mercury pollution is one of the most pressing environmental problems. Therefore, the impact of mercury on human body, the nervous system in particular, remains topical. The aim of the study was to identify the morphological characteristics of neurons and neuroglia in spinal ganglia of rats receiving antioxidants in the presence of small doses of mercury (II) chloride.
Materials and methods: A total of 100 white Wistar rats were divided into 5 series (10 groups), with 10 animals in each group. The first series comprised intact animals receiving saline solution instead of drugs administered in other series (control). In the second series 10 injections of mercury (II) chloride were performed (group of short-term neurointoxication) and 50 injections (group of long-term neurointoxication). In the third to the fifth series, the short- and long-term neurointoxication was followed by 10 daily injection of the drugs: unithiolum, thiotriazolinum and mildronate respectively. Spinal ganglia were obtained two weeks after the completion of drugs administration and studied microscopically and ultramicroscopically.
Results: Administration of thiotriazolinum, unithiolum and mildronate mitigated manifestations of toxic effects of mercury (II) chloride on spinal ganglia. Unithiolum and thiotria-zolinum activated synthetic processes, while mildronate had a positive effect on restoration of cells metabolism.
Conclusions: Morphological data show that unithiolum and thiotriazolinum action decreases toxic effects of mercury chloride and are similar. They demonstrate pronounced activation of synthetic processes in sensory neurons and satellite cells of spinal ganglia. Mildronate also restores cell ultrastructure and has more pronounced effect on their energetic processes and interaction between neurons and satellite cells.
Keywords: Mercury chloride; Antioxidants; Neurons; Satellite cells Mercury chloride; Antioxidants; Neurons; Satellite cells
This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License (CC BY-NC-ND) (CC BY-NC-ND).

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Sokurenko, L.M.; Savchyna, M.O.; Litus, V.I.; Kaminsky, R.F.; Ehaikovsky, Y.B. Rat spinal ganglia in assessment of protective action of antioxidants: A morphological study. Medicina 2017, 53, 316-322.

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