Factors influencing renal graft survival: 7-Year experience of a single center
Materials and methods: We analyzed the influence of deceased donor and recipient factors and histological findings on the graft function in 186 renal transplant patients. Graft survival was estimated within the first year after transplantation.
Results: The donors and recipients were older in worse eGFR group 1 year after transplantation. Dissimilarity of degree of glomerulosclerosis (GS), interstitial fibrosis (IF) and arteriolar hyalinosis (AH) were significant in inferior and superior renal function groups (GS >20% 11.4 vs. 0%, P = 0.017; IF 9.3 vs. 0%, P = 0.034; AH 69 vs. 26.2%, P < 0.001). Nine independent variables were significantly associated with a worse renal transplant function 1 year posttransplantation: AH (OR = 6.287, P < 0.001), an episode of urinary tract infection (OR = 2.769, P = 0.020), acute graft rejection (OR = 3.605, P = 0.037), expanded criteria (OR = 4.987, P = 0.001), female gender donors (OR = 3.00, P = 0.014), cerebrovascular disease caused donor brain death (OR = 5.00, P = 0.001), donor's age (OR = 1.07, P < 0.001), and recipient's age (OR = 1.047, P = 0.022). Worse renal graft survival 1 year posttransplantation was associated with a delayed graft function and a higher level of glomerulosclerosis in time-zero biopsy.
Conclusions: Donor factors, such as age, female gender, brain death of cerebrovascular cause and expanded criteria donor status had a significant negative impact on the renal graft function 1 year after transplantation. Recipients' age, urinary tract infection and acute graft rejection episodes after transplantation were associated with a worse kidney function 1 year after transplantation. Lower 1-year graft survival was related to a delayed graft function (DGF) and a higher degree of glomerulosclerosis.
Auglienė, R.; Dalinkevičienė, E.; Kuzminskis, V.; Jievaltas, M.; Peleckaitė, L.; Gryguc, A.; Stankevičius, E.; Bumblytė, I.A. Factors influencing renal graft survival: 7-Year experience of a single center. Medicina 2017, 53, 224-232.
Auglienė R, Dalinkevičienė E, Kuzminskis V, Jievaltas M, Peleckaitė L, Gryguc A, Stankevičius E, Bumblytė IA. Factors influencing renal graft survival: 7-Year experience of a single center. Medicina. 2017; 53(4):224-232.Chicago/Turabian Style
Auglienė, Rūta; Dalinkevičienė, Eglė; Kuzminskis, Vytautas; Jievaltas, Mindaugas; Peleckaitė, Laima; Gryguc, Agnė; Stankevičius, Edgaras; Bumblytė, Inga Arūnė. 2017. "Factors influencing renal graft survival: 7-Year experience of a single center." Medicina 53, no. 4: 224-232.