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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
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Medicina 2017, 53(3), 190-202; https://doi.org/10.1016/j.medici.2017.05.002 (registering DOI)

A role of alpha-tocopherol and phylloquinone in the modulation of uterine contractility and reproductive function in mouse models

1
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Nigeria
2
Department of Science Laboratory Technology, Faculty of Life Sciences, University of Benin, Nigeria
3
Department of Anatomy, School of Basic Medical Sciences, University of Benin, Nigeria
4
Hematology Department, University of Benin Teaching Hospital, Benin City, Nigeria
5
Histopathology Department, University of Benin Teaching Hospital, Benin City, Nigeria
*
Author to whom correspondence should be addressed.
Received: 3 October 2016 / Revised: 5 April 2017 / Accepted: 8 May 2017 / Published: 30 May 2017
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Abstract

Background and aim: Alpha-tocopherol has been implicated in reproduction processes, and deficiency of phylloquinone has been associated with serious complications in pregnancy. This study was therefore aimed at investigating the effects of phylloquinone and alphatocopherol on uterine contractility and female reproductive function using mouse models.
Materials and methods: Both in vivo and ex vivo animal models were employed and designed to assess changes on uterine contractility and reproductive functions in the non-pregnant uterus. The effect of alpha-tocopherol and phylloquinone on spontaneous uterine contractions, oxytocin-induced uterine contractions (11.82 nM) and high KCl-induced tonic uterine contractions (80 mM) were assessed. The effect of subcutaneous administration of alphatocopherol (10 mg/kg) on reproductive hormone levels and reproductive tissues were also determined.
Results: Alpha-tocopherol increased the force of contractions while phylloquinone decreased the force of uterine contractions. Plasma levels of luteinizing hormone (P < 0.01), estrogen (P < 0.01) and progesterone (P < 0.001) were elevated in the presence of alphatocopherol after 6 days subcutaneous administration.
Conclusions: Alpha-tocopherol and phylloquinone have been shown to directly modulate uterine contractility and reproductive function and may contribute to the management and treatment of reproductive disorders.
Keywords: Alpha-tocopherol; Phylloquinone; Uterine contractility; Vitamin E; Vitamin K Alpha-tocopherol; Phylloquinone; Uterine contractility; Vitamin E; Vitamin K
This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License (CC BY-NC-ND) (CC BY-NC-ND).

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Bafor, E.E.; Ebidame, V.O.; Elvis-Offiah, U.B.; Omoruyi, O.; Eze, G.I.; Igbinuwen, O.; Braimoh, K.P. A role of alpha-tocopherol and phylloquinone in the modulation of uterine contractility and reproductive function in mouse models. Medicina 2017, 53, 190-202.

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