Next Article in Journal
Factors affecting primary patency of stenting for TransAtlantic Inter-Society (TASC II) type B, C, and D iliac occlusive disease
Previous Article in Journal
Comparison of the improvement in myocardial perfusion and function in cases of rapid and slow electrocardiographic stage dynamics between patients with TIMI-3 flow after primary angioplasty for acute myocardial infarction
Article Menu

Article Versions

Export Article

Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle
Medicina 2017, 53(3), 159-165; https://doi.org//10.1016/j.medici.2017.05.003 (registering DOI)

Use of interferon-gamma release assay and tuberculin skin test in diagnosing tuberculosis in Lithuanian adults: A comparative analysis

1
Department of Immunology and Allergology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
2
Department of Paediatrics, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
3
Department of Laboratory Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
4
Department of Pulmonology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
5
Department of Internal Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 15 June 2016 / Revised: 8 February 2017 / Accepted: 18 May 2017 / Published: 3 July 2017
PDF [559 KB, uploaded 26 February 2018]

Abstract

Background and objective: Lithuania belongs to the group of countries with a high-incidence of tuberculosis (TB). Some scientific studies show that the interferon-gamma release assay is more accurate and correlates more highly with TB exposure as compared to the tuberculin skin test (TST). This study aimed at comparing the efficacy between the T SPOT TB and TST for diagnosing TB among Lithuanian adults.
Materials and methods: Individuals with diagnosed TB, healthcare workers with known risk for TB and individuals without any known risk for TB underwent clinical examinations, interviews about their history of TB exposure and chest radiography. Then the TST and the T SPOT TB were performed on patients.
Results: A positive T SPOT TB was more common in the group with diagnosed TB compared to healthcare workers and the low risk for TB groups (97.5%, 36.4%, and 0%, respectively, P < 0.01). Positive TST results did not differ between the groups with diagnosed TB and the healthcare workers (92.5% vs. 95.5%, P > 0.05). Agreement between TST and T SPOT TB was poor (kappa 0.14, P > 0.05). T SPOT TB had higher specificity and sensitivity compared to TST (area under the ROC 0.9 ± 0.04, P < 0.01, vs. 0.5 ± 0.06, P > 0.05).
Conclusions: The T SPOT TB showed greater accuracy in diagnosing TB than TST did. Positive T SPOT TB result but not the TST was more common in patients with diagnosed TB.
Keywords: Tuberculosis; Tuberculin skin test; Interferon-gamma release assay; T SPOT TB Tuberculosis; Tuberculin skin test; Interferon-gamma release assay; T SPOT TB
This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License (CC BY-NC-ND) (CC BY-NC-ND).

Share & Cite This Article

MDPI and ACS Style

Tamašauskienė, L.; Hansted, E.; Vitkauskienė, A.; Miliauskas, S.; Naudžiūnas, A.; Šitkauskienė, B. Use of interferon-gamma release assay and tuberculin skin test in diagnosing tuberculosis in Lithuanian adults: A comparative analysis. Medicina 2017, 53, 159-165.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Medicina EISSN 1010-660X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top