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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
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Alternans in atria: Mechanisms and clinical relevance

Department of Physiology & Biophysics, Rush University Medical Center, Chicago, USA
Author to whom correspondence should be addressed.
Medicina 2017, 53(3), 139-149;
Received: 21 April 2017 / Accepted: 25 April 2017 / Published: 7 June 2017
Atrial fibrillation is the most common sustained arrhythmia and its prevalence is rapidly rising with the aging of the population. Cardiac alternans, defined as cyclic beat-to-beat alternations in contraction force, action potential (AP) duration and intracellular Ca2+ release at constant stimulation rate, has been associated with the development of ventricular arrhythmias. Recent clinical data also provide strong evidence that alternans plays a central role in arrhythmogenesis in atria. The aim of this article is to review the mechanisms that are responsible for repolarization alternans and contribute to the transition from spatially concordant alternans to the more arrhythmogenic spatially discordant alternans in atria. View Full-Text
Keywords: Alternans; Atria; Arrhythmias; Action potential; Calcium signaling Alternans; Atria; Arrhythmias; Action potential; Calcium signaling
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Kanaporis, G.; Blatter, L.A. Alternans in atria: Mechanisms and clinical relevance. Medicina 2017, 53, 139-149.

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