Next Article in Journal
Peripheral blood Th9 cells and eosinophil apoptosis in asthma patients
Previous Article in Journal
Importance of alcohol-related expectations and emotional expressivity for prediction of motivation to refuse alcohol in alcohol-dependent patients
Article Menu

Export Article

Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessReview
Medicina 2017, 53(3), 139-149; https://doi.org/10.1016/j.medici.2017.04.004 (registering DOI)

Alternans in atria: Mechanisms and clinical relevance

Department of Physiology & Biophysics, Rush University Medical Center, Chicago, USA
*
Author to whom correspondence should be addressed.
Received: 21 April 2017 / Accepted: 25 April 2017 / Published: 7 June 2017
Full-Text   |   PDF [1762 KB, uploaded 25 February 2018]   |  

Abstract

Atrial fibrillation is the most common sustained arrhythmia and its prevalence is rapidly rising with the aging of the population. Cardiac alternans, defined as cyclic beat-to-beat alternations in contraction force, action potential (AP) duration and intracellular Ca2+ release at constant stimulation rate, has been associated with the development of ventricular arrhythmias. Recent clinical data also provide strong evidence that alternans plays a central role in arrhythmogenesis in atria. The aim of this article is to review the mechanisms that are responsible for repolarization alternans and contribute to the transition from spatially concordant alternans to the more arrhythmogenic spatially discordant alternans in atria. View Full-Text
Keywords: Alternans; Atria; Arrhythmias; Action potential; Calcium signaling Alternans; Atria; Arrhythmias; Action potential; Calcium signaling
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License (CC BY-NC-ND) (CC BY-NC-ND).

Share & Cite This Article

MDPI and ACS Style

Kanaporis, G.; Blatter, L.A. Alternans in atria: Mechanisms and clinical relevance. Medicina 2017, 53, 139-149.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Medicina EISSN 1010-660X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top