Next Article in Journal
Effect of probiotics on glucose metabolism in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials
Previous Article in Journal
Reirradiation for patients with recurrence head and neck squamous cell carcinoma: A single-institution comparative study
Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Left atrial mechanics in patients with acute STEMI and secondary mitral regurgitation: A prospective pilot CMR feature tracking study

1
Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
2
Department of Internal Medicine II, University Clinic Giessen–Marburg, Giessen, Germany
3
Department of Cardiac, Thoracic and Vascular Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
4
Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Medicina 2017, 53(1), 11-18; https://doi.org/10.1016/j.medici.2017.02.001
Received: 1 December 2016 / Revised: 22 January 2017 / Accepted: 11 February 2017 / Published: 1 March 2017
Background and objective: Left atrium (LA) is an important biomarker of adverse cardiovascular outcomes and cerebrovascular events. This study aimed to evaluate LA myocardial deformation using cardiac magnetic resonance feature tracking (CMR-FT) in patients with acute ST-segment elevation myocardial infarction (STEMI) and secondary mitral regurgita- tion (MR). Additionally, to assess interobserver and intraobserver variability of the technique.Materials and methods: Twenty patients with STEMI underwent CMR with a 1.5 Tesla MRI scanner. According to the presence of MR patients were divided into two groups: MR(+) and MR(−). Total LA strain (εs), passive LA strain (εe), and active LA strain (εa) were obtained. Additionally, total, passive and active strain rates (SRs, SRe, and SRa) were calculated. To assess interobserver agreement data analysis was performed by second independent observer.Results: LA volumetric and functional parameters were similar in both groups. All LA strain values were significantly higher in patients with MR: εs (27.67 ± 10.25 for MR(−) vs. 32.80 ± 6.95 for MR(+); P = 0.01), εe (15.29 ± 7.30 for MR(−) vs. 19.22 ± 6.04 for MR(+); P = 0.01) and εa (12.38 ± 4.23 for MR(−) vs. 14.44 ± 5.19 for MR(+); P = 0.03). Only SRe significantly increased in patients with MR (−0.57 ± 0.24 for MR(−) vs. −0.70 ± 0.20 for MR(+); P = 0.01). All LA deformation parameters demonstrated high interobserver and intraobserver agreement. Conclusions: Conventional volumetric and functional LA parameters do not detect early changes in LA performance in patients with STEMI and secondary MR. In contrast, LA reservoir, passive and active strain are significantly higher in patients with MR. Only peak early negative strain rate substantially increases during secondary MR. LA deformation parameters derived from conventional cine images using CMR-FT technique are highly reproducible.
Keywords: Cardiac magnetic resonance; Feature tracking; Myocardial deformation; Left atrium; Reproducibility Cardiac magnetic resonance; Feature tracking; Myocardial deformation; Left atrium; Reproducibility
MDPI and ACS Style

Lapinskas, T.; Bučius, P.; Urbonaitė, L.; Stabinskaitė, A.; Valuckienė, Ž.; Jankauskaitė, L.; Benetis, R.; Žaliūnas, R. Left atrial mechanics in patients with acute STEMI and secondary mitral regurgitation: A prospective pilot CMR feature tracking study. Medicina 2017, 53, 11-18.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Back to TopTop