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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessReview

Management of recurrent aphthous ulcers using low-level lasers: A systematic review

Restorative Dental Sciences, Al Farabi Colleges, Riyadh, Saudi Arabia
Department of Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa, Saudi Arabia
Department of Biomedical Engineering, College of Engineering, King Faisal University, Al-Ahsa, Saudi Arabia
School of Dentistry, Riyadh College of Dentistry and Pharmacy, Riyadh, Saudi Arabia
Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom
Restorative Dentistry Department, College of Dentistry, Taibah University, Madinah Munawarrah, Saudi Arabia
Author to whom correspondence should be addressed.
Medicina 2016, 52(5), 263-268;
Received: 30 November 2015 / Revised: 5 July 2016 / Accepted: 21 July 2016 / Published: 15 September 2016
Background and objective: The exact etiology of recurrent aphthous ulcers (RAS) is unknown. The management of RAS is not always straightforward. The aim of this review is to critically analyze and summarize the clinical literature focusing on the management of aphthous ulcers using low-level lasers.
Materials and methods: The Medline (PubMed), Web of Knowledge (ISI), Cochrane Central Register of Controlled Trials (CENTRAL) and Embase databases were searched electronically for studies published in last 20 years (1995–2015) using the keywords ‘‘recurrent aphthous stomatitis,’’ ‘‘aphthous ulcers,’’ and ‘‘laser.’’
Results: A total of 85 articles were found during the initial search; 76 studies were excluded for not fulfilling the criteria whereas nine studies were deemed suitable for this review. Among the included studies, two articles were case reports and seven were randomized clinical trials. Study design, sample size, type of intervention and control of each study were critically analyzed and summarized according to the CONSORT protocol. In majority of the patients, immediate pain relief and accelerated ulcer healing was observed following irradiation with lasers.
Conclusions: Although various types of lasers have succeeded in providing immediate pain relief to patients, carbon dioxide (CO2) lasers have the unique advantage of requiring a short exposure time (5–10 s). In order to ascertain the efficacy of laser for treating ulcers in the clinical setting, more clinical trials are required.
Keywords: Sore mouth; Stomatitis; Aphthous ulcers; Pain relief; Healing Sore mouth; Stomatitis; Aphthous ulcers; Pain relief; Healing
MDPI and ACS Style

Najeeb, S.; Khurshid, Z.; Zohaib, S.; Najeeb, B.; Qasim, S.B.; Zafar, M.S. Management of recurrent aphthous ulcers using low-level lasers: A systematic review. Medicina 2016, 52, 263-268.

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