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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

The acute effects of passive heat exposure on arterial stiffness, oxidative stress, and inflammation

1
Institute of Exercise Biology and Physiotherapy, University of Tartu, Tartu, Estonia
2
Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tartu, Estonia
3
Department of Cardiology, University of Tartu, Tartu, Estonia
4
Department of Sports Medicine and Rehabilitation, University of Tartu, Tartu, Estonia
5
Sports Medicine and Rehabilitation Clinic, Tartu University Hospital, Tartu, Estonia
6
Institute of Biomedicine and Translational Medicine, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia
7
Department of Vascular Surgery, Tartu University Hospital, Tartu, Estonia
*
Author to whom correspondence should be addressed.
Medicina 2016, 52(4), 211-216; https://doi.org/10.1016/j.medici.2016.06.001
Received: 9 May 2015 / Revised: 20 May 2016 / Accepted: 14 June 2016 / Published: 29 June 2016
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Abstract

Background and objective: The aim of the study was to determine the acute effect of passive heat exposure (PHE) on arterial stiffness, oxidative stress (OxS) and inflammatory parameters.
Materials and methods: Subjects were studied in thermoneutral conditions before and after PHE in a climatic chamber. Pulse wave analysis was used for assessment of central hemodynamic and arterial stiffness parameters. Venous blood samples were obtained to measure OxS and inflammatory parameters.
Results: Rectal temperature increased after PHE exposure compared to baseline: 37.01 °C ± 0.19 °C and 36.4 °C ± 0.31 °C, respectively (P < 0.001). There was a 17% (P < 0.05) decrease in large artery elasticity index (from 24.68 ± 5.53 to 20.42 ± 2.65 mL/mmHg*10), which was predicted upon normothermic value (r = −0.878, P < 0.01). However, no significant changes were found in others arterial stiffness parameters. A 30% (P < 0.05) increase occurred in blood IL-6 concentration (from 0.43 ± 0.15 to 0.56 ± 0.23 pg/mL), but OxS parameters remained significantly unchanged.
Conclusions: This study describes for the first time acute PHE effects on arterial stiffness, inflammation and OxS. PHE significantly decreases large artery elasticity index and increases inflammatory IL-6 level. However, further larger investigations are needed for clarifying acute PHE effects on arterial function and biomarkers.
Keywords: Arterial elasticity; Climatic chamber; Pulse wave analysis; Heat stress Arterial elasticity; Climatic chamber; Pulse wave analysis; Heat stress
This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License (CC BY-NC-ND) (CC BY-NC-ND).
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Kaldur, T.; Unt, E.; Ööpik, V.; Zilmer, M.; Eha, J.; Paapstel, K.; Kals, J. The acute effects of passive heat exposure on arterial stiffness, oxidative stress, and inflammation. Medicina 2016, 52, 211-216.

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