N-carboxymethyllysine as a biomarker for coronary artery disease and age-related macular degeneration
Materials and methods: The study enrolled 233 subjects. Based on cardiologic and ophthal- mologic examinations, the patients were divided into four subgroups: CADath+ARMD+, CADath+ARMD−, CADath−ARMD+, and CADath−ARMD−. The enzyme-linked immunosorbent assay was used for the measurement of plasma CML levels. Serum lipid levels were determined by an automatic analyzer using conventional enzymatic methods.
Results: CADath+ patients had higher CML concentration compared to CADath subjects (1.04 ± 0.6 vs. 0.83 ± 0.4 ng/mL, P < 0.001). The highest mean CML level (1.12 ± 0.7 ng/mL) was found in CADath+ARMD+ patients. The mean plasma CML concentration was higher in subjects with any of the analyzed diseases compared to CADath−ARMD− subjects. A significant positive association of CADath+ (OR = 2.50, 95% CI 1.60–3.90, P = 0.0001), ARMD (OR = 2.08, 95% CI 1.40–3.11, P = 0.0001) and both analyzed diseases (OR = 4.67, 95% CI 2.29– 9.53, P = 0.0001) with an increased level of plasma CML in a logistic regression model adjusting by age was identified.
Conclusions: The level of CML, an oxidative stress biomarker, reflects the presence of atherosclerosis in coronary arteries and shows a possible link between ARMD and CADath+ via oxidative status.
Stanislovaitienė, D.; Žaliūnienė, D.; Steponavičiūtė, R.; Žemaitienė, R.; Gustienė, O.; Žaliūnas, R. N-carboxymethyllysine as a biomarker for coronary artery disease and age-related macular degeneration. Medicina 2016, 52, 99-103.
Stanislovaitienė D, Žaliūnienė D, Steponavičiūtė R, Žemaitienė R, Gustienė O, Žaliūnas R. N-carboxymethyllysine as a biomarker for coronary artery disease and age-related macular degeneration. Medicina. 2016; 52(2):99-103.Chicago/Turabian Style
Stanislovaitienė, Daiva; Žaliūnienė, Dalia; Steponavičiūtė, Rasa; Žemaitienė, Reda; Gustienė, Olivija; Žaliūnas, Remigijus. 2016. "N-carboxymethyllysine as a biomarker for coronary artery disease and age-related macular degeneration." Medicina 52, no. 2: 99-103.