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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
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Hypertension and physical exercise: The role of oxidative stress

Department of Biomedicine, Faculty of Health, Aarhus University, Aarhus, Denmark
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Author to whom correspondence should be addressed.
Medicina 2016, 52(1), 19-27; https://doi.org/10.1016/j.medici.2016.01.005
Received: 29 November 2015 / Revised: 15 January 2016 / Accepted: 17 January 2016 / Published: 29 January 2016
Oxidative stress is associated with the pathogenesis of hypertension. Decreased bioavailability of nitric oxide (NO) is one of the mechanisms involved in the pathogenesis. It has been suggested that physical exercise could be a potential non-pharmacological strategy in treatment of hypertension because of its beneficial effects on oxidative stress and endothelial function. The aim of this review is to investigate the effect of oxidative stress in relation to hypertension and physical exercise, including the role of NO in the pathogenesis of hypertension. Endothelial dysfunction and decreased NO levels have been found to have the adverse effects in the correlation between oxidative stress and hypertension. Most of the previous studies found that aerobic exercise significantly decreased blood pressure and oxidative stress in hypertensive subjects, but the intense aerobic exercise can also injure endothelial cells. Isometric exercise decreases normally only systolic blood pressure. An alternative exercise, Tai chi significantly decreases blood pressure and oxidative stress in normotensive elderly, but the effect in hypertensive subjects has not yet been studied. Physical exercise and especially aerobic training can be suggested as an effective intervention in the prevention and treatment of hypertension and cardiovascular disease via reduction in oxidative stress.
Keywords: Oxidative stress; Hypertension; Exercise; Redox state; Nitric oxide Oxidative stress; Hypertension; Exercise; Redox state; Nitric oxide
MDPI and ACS Style

Larsen, M.K.; Matchkov, V.V. Hypertension and physical exercise: The role of oxidative stress. Medicina 2016, 52, 19-27.

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