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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Evaluation of vitamin D levels in allergic and non-allergic asthma

Department of Pulmonology and Immunology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
Author to whom correspondence should be addressed.
Medicina 2015, 51(6), 321-327;
Received: 7 October 2014 / Revised: 23 September 2015 / Accepted: 10 November 2015 / Published: 24 November 2015
Background and objective: Some researches show that low vitamin D may play a role in asthma pathogenesis. The aim of this study was to evaluate the serum vitamin D level in asthmatics with different phenotypes and to determine its associations with lung function, IgE, eosinophil count and body mass index (BMI).
Materials and methods: The study population comprised 85 patients with asthma and 73 healthy persons. Patients with asthma were divided into groups according to phenotypes. Allergy was assessed using a skin prick test and measuring eosinophil count in peripheral blood and total IgE in serum. Lung function was evaluated by spirometry. Concentration of vitamin D (25(OH)D3) was measured using a commercial ELISA kit. Smoking history was assessed and BMI was calculated for all individuals.
Results: The vitamin D level was lower in asthmatics than in the control group (14.36 ± 0.57 vs. 22.13 ± 0.84 ng/mL, P < 0.01). There were no significant differences in the vitamin D level between the groups with allergic and non-allergic asthma (14.36 ± 0.77 vs. 14.35 ± 0.74 ng/ mL). The low vitamin D level increased the risk of asthma 1.2 times (OR, 1.194; 95% CI, 1.109– 1.286, P < 0.01). The vitamin D level did not correlate with lung function and markers of allergy in asthmatic patients. The vitamin D level correlated with FEV1/FVC (rs = 0.72, P < 0.05) in smoking patients with asthma. Correlation between the vitamin D level and BMI was found in all studied subjects (rs = −0.18, P < 0.05).
Conclusions: The vitamin D level was lower in asthmatic patients than in healthy individuals despite their hypersensitivity and increase risk of asthma. There was no relation between the vitamin D level and lung function, eosinophil count and total IgE level, whereas the lower vitamin D level was associated with higher BMI.
Keywords: Vitamin D; Asthma; Allergy; Lung function; Body mass index Vitamin D; Asthma; Allergy; Lung function; Body mass index
MDPI and ACS Style

Tamašauskienė, L.; Gasiūnienė, E.; Lavinskienė, S.; Sakalauskas, R.; Šitkauskienė, B. Evaluation of vitamin D levels in allergic and non-allergic asthma. Medicina 2015, 51, 321-327.

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