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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

The influence of the extended indications for sentinel node biopsy on the identification of metastasis-free and metastatic sentinel nodes

1
Department of Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
2
Laboratory of Surgical Gastroenterology, Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2015, 51(5), 291-295; https://doi.org/10.1016/j.medici.2015.10.001
Received: 29 January 2014 / Accepted: 2 October 2015 / Published: 28 October 2015
Background and objective: Rates of sentinel node (SN) identification and metastasis-positive SNs were compared between the group with highly selective indications for sentinel node biopsy (SNB) and the group with merely no contraindications for SNB (Groups A and B, respectively).
Materials and methods: We performed a single-center retrospective data analysis of 471 breast cancer patients treated during 2004–2010. Data on clinical and pathologic staging, frozen section results, radiological measurements and pathologic examination results were obtained from patient records. Patients were analyzed in two groups. Group A (n = 143) had SNB performed only when the patients fulfilled to the following criteria: breast tumor no greater than 3 cm in diameter, unifocal disease, no pure ductal carcinoma in situ, no history of previous breast or lymph node surgery, and no neoadjuvant chemotherapy. Indications for SNB were extended in Group B (n = 328) so that inflammatory breast cancer and positive lymph nodes became the only exclusion criteria.
Results: The rate of SN identification was 97.9% in Group A vs. 99.09% in Group B (P = 0.29). SNs were metastasis positive and frozen sections false negative at comparable proportions in both groups.
Conclusions: The extension of indications for SNB did not reduce the rates of SN identification or did not create any impact on the rate of metastatic SNs.
Keywords: Sentinel node biopsy; Identification rate; Metastatic sentinel node rate; False negative rate Sentinel node biopsy; Identification rate; Metastatic sentinel node rate; False negative rate
MDPI and ACS Style

Martinaitis, L.; Dambrauskas, Ž.; Boguševičius, A. The influence of the extended indications for sentinel node biopsy on the identification of metastasis-free and metastatic sentinel nodes. Medicina 2015, 51, 291-295.

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