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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Temperature influencing permeation pattern of alfuzosin: An investigation using DoE

1
Talla Padmavathi College of Pharmacy, Orus, Warangal, India
2
School of Pharmaceutical Sciences, SOA University, Bhubaneswar, Orissa, India
*
Author to whom correspondence should be addressed.
Medicina 2015, 51(4), 253-261; https://doi.org/10.1016/j.medici.2015.07.002
Received: 3 October 2014 / Revised: 11 July 2015 / Accepted: 15 July 2015 / Published: 30 July 2015
Background and objective: There has been relatively little investigation of the effect of temperature on skin permeation compared to other methods of penetration enhance-ment. A principal physicochemical factor which controls the passive diffusion of a solute from a vehicle into the skin arises from the skin temperature. The aim of this ex vivo study was to probe into the effect of heat on transdermal absorption of alfuzosin hydrochloride from ethyl cellulose-polyvinyl pyrrolidone (EC-PVP) based transdermal systems.
Materials and methods: Principles of design of experiment (DoE) were used to systematically study the influence of temperature on transdermal permeation of alfuzosin. Ex vivo transdermal permeation studies were carried out at varied donor compartment tempera-tures. Permeation data analysis was carried out and activation energy for transdermal permeation was estimated.
Results: Temperature found to enhance ex vivo permeation parameters of alfuzosin hy-drochloride from its transdermal systems. It was also noted that chemical permeation enhancers potentiate permeation enhancing effect of temperature. The permeation flux values approximately doubled after exposure to 45 °C. The activation energy for transder-mal permeation was found lower for the runs with chemical permeation enhancers indicating existence of a lower energy barrier in the presence of chemical permeation enhancers.
Conclusion: The method reported here is a simple and useful tool for studying the effect of heat on percutaneous absorption. Such temperature dependent enhancement of flux can be more pronounced at skin surface temperatures >45 °C.
Keywords: Alfuzosin hydrochloride; Transdermal delivery; Temperature; Permeation enhancer; Ex vivo Alfuzosin hydrochloride; Transdermal delivery; Temperature; Permeation enhancer; Ex vivo
MDPI and ACS Style

Pattnaik, S.; Swain, K.; Rao, J.V.; Varun, T.; Mallick, S. Temperature influencing permeation pattern of alfuzosin: An investigation using DoE. Medicina 2015, 51, 253-261.

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