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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Impact of left ventricular function on health-related quality of life in coronary artery disease patients

1
Behavioral Medicine Institute, Medical Academy, Lithuanian University of Health Sciences, Palanga, Lithuania
2
Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2015, 51(4), 233-239; https://doi.org/10.1016/j.medici.2015.07.005
Received: 16 July 2014 / Accepted: 13 July 2015 / Published: 1 August 2015
Objective: The aim of the study was to investigate the relation between health-related quality of life (HRQoL) and left ventricular systolic and diastolic function parameters in stable coronary artery disease (CAD) patients with mild and moderate heart failure.
Materials and methods: This study included 758 CAD patients. Left ventricular ejection fraction (LVEF) and ratio of peak velocities of early (E) and late (A) diastolic mitral inflow, ratio E/A, deceleration time, isovolumic relaxation time were assessed. Patients completed the SF-36 questionnaire.
Results: There were no strong and significant associations between echocardiographic measures and HRQoL in NYHA I-II class patients. In NYHA III class in univariate linear regression analyses significant associations were found between LVEF and physical functioning (β = 0.230, P = 0.009) and role limitations due to physical problems (β = 0.230, P = 0.009) and these associations remain significant after adjustment for age, gender, hypertension, angina pectoris class, nitrate, ACE inhibitors and diuretics use. E/A ratio was significantly associated only with mental health domain (β = 0.188, P = 0.048), and this association remains significant after all adjustments.
Conclusions: In stable CAD patients with NYHA I-II functional class HRQoL was not strongly associated with left ventricular function; in NYHA III functional class patients' greater systolic function mainly was associated with better physical health and better diastolic function, with better mental health.
Keywords: Left ventricular function; Health-related quality of life; Coronary artery disease Left ventricular function; Health-related quality of life; Coronary artery disease
MDPI and ACS Style

Staniūtė, M.; Vaškelytė, J.; Rumbinaitė, E.; Kaminskaitė, B.; Samsanavičienė, S.; Plungienė, S.; Brožaitienė, J.; Bunevičius, R. Impact of left ventricular function on health-related quality of life in coronary artery disease patients. Medicina 2015, 51, 233-239.

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