Impact of left ventricular function on health-related quality of life in coronary artery disease patients
Materials and methods: This study included 758 CAD patients. Left ventricular ejection fraction (LVEF) and ratio of peak velocities of early (E) and late (A) diastolic mitral inflow, ratio E/A, deceleration time, isovolumic relaxation time were assessed. Patients completed the SF-36 questionnaire.
Results: There were no strong and significant associations between echocardiographic measures and HRQoL in NYHA I-II class patients. In NYHA III class in univariate linear regression analyses significant associations were found between LVEF and physical functioning (β = 0.230, P = 0.009) and role limitations due to physical problems (β = 0.230, P = 0.009) and these associations remain significant after adjustment for age, gender, hypertension, angina pectoris class, nitrate, ACE inhibitors and diuretics use. E/A ratio was significantly associated only with mental health domain (β = 0.188, P = 0.048), and this association remains significant after all adjustments.
Conclusions: In stable CAD patients with NYHA I-II functional class HRQoL was not strongly associated with left ventricular function; in NYHA III functional class patients' greater systolic function mainly was associated with better physical health and better diastolic function, with better mental health.
Staniūtė, M.; Vaškelytė, J.; Rumbinaitė, E.; Kaminskaitė, B.; Samsanavičienė, S.; Plungienė, S.; Brožaitienė, J.; Bunevičius, R. Impact of left ventricular function on health-related quality of life in coronary artery disease patients. Medicina 2015, 51, 233-239.
Staniūtė M, Vaškelytė J, Rumbinaitė E, Kaminskaitė B, Samsanavičienė S, Plungienė S, Brožaitienė J, Bunevičius R. Impact of left ventricular function on health-related quality of life in coronary artery disease patients. Medicina. 2015; 51(4):233-239.Chicago/Turabian Style
Staniūtė, Margarita; Vaškelytė, Jolanta; Rumbinaitė, Eglė; Kaminskaitė, Birutė; Samsanavičienė, Sigita; Plungienė, Sigita; Brožaitienė, Julija; Bunevičius, Robertas. 2015. "Impact of left ventricular function on health-related quality of life in coronary artery disease patients." Medicina 51, no. 4: 233-239.