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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Correlation of magnesium deficiency with C-reactive protein in elective cardiac surgery with cardiopulmonary bypass for ischemic heart disease

1
Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
2
Department of Cardiothoracic and Vascular Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
3
Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
4
Department of Intensive Care, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2015, 51(2), 100-106; https://doi.org/10.1016/j.medici.2015.03.003
Received: 23 January 2014 / Accepted: 1 March 2015 / Published: 1 April 2015
Background and objective: Cardiac surgery is associated with systemic inflammatory response, which is triggered by cardiopulmonary bypass (CPB) and possibly with underlying magnesium deficiency. Animal studies have shown that magnesium deficiency intensifies oxidative stress and inflammatory processes. We aimed to find a link between serum, erythrocyte, cardiac tissue magnesium concentration and C-reactive protein (CRP) as an inflammatory marker in patients undergoing elective cardiac surgery with CPB.
Materials and methods: The data of 27 patients undergoing elective cardiac surgery with CPB for ischemic heart disease were analyzed. Measurements were taken at the baseline, i.e., 24 h before surgery (serum magnesium, CRP); time point 1, before CPB (serum, erythrocyte and cardiac tissue magnesium); time point 2, after CPB (serum, erythrocyte and cardiac tissue magnesium), and time point 3, 15–17 h after surgery (serum, erythrocyte magnesium, CRP).
Results: There was a negative correlation between baseline serum magnesium and baseline CRP (P = 0.009; r = 0.492), negative correlation between cardiac tissue magne- sium at the time point 1 and baseline CRP (P = 0.021; r = 0.443), and positive correlation between CRP at time point 3 and erythrocyte magnesium at time point 2 (P < 0.001; r = 0.637).
Conclusions: The data of our study verify that inflammatory marker CRP and magnesium concentration in serum and cardiac tissue before the surgery are inversely related in patients undergoing elective cardiac surgery with CPB. Well-planned further studies are needed to evaluate the importance of underlying magnesium deficiency on the severity of systemic inflammatory response and postoperative complications after surgery with CPB.
Keywords: Magnesium concentration; C-reactive protein; Coronary bypass graft surgery; Cardiopulmonary bypass; Ischemic heart disease Magnesium concentration; C-reactive protein; Coronary bypass graft surgery; Cardiopulmonary bypass; Ischemic heart disease
MDPI and ACS Style

Švagždienė, M.; Širvinskas, E.; Baranauskienė, D.; Adukauskienė, D. Correlation of magnesium deficiency with C-reactive protein in elective cardiac surgery with cardiopulmonary bypass for ischemic heart disease. Medicina 2015, 51, 100-106.

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