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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Use of exploratory factor analysis to ascertain the correlation between the activities of rheumatoid arthritis and infection by human parvovirus B19

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Daugavpils Regional Hospital, Daugavpils, Latvia
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Department of Internal Diseases, Riga Stradins University, Riga, Latvia
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August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia
*
Author to whom correspondence should be addressed.
Medicina 2015, 51(1), 18-24; https://doi.org/10.1016/j.medici.2015.01.004
Received: 9 June 2013 / Accepted: 15 January 2015 / Published: 28 January 2015
Background and objective: We evaluated a possible correlation between the clinical activities of rheumatoid arthritis (RA) and human parvovirus B19 (B19) infection using exploratory factor analysis (EFA).
Materials and methods: RA patients were organized into two groups: 100 patients in the main groupand97intheRA(DAS28)group.Foursubgroupsweredefinedfromthemaingroupaccording to the presence or absence of certain infection-specific markers: group I comprised 43 patients whohadIgGantibodiesagainstB19;groupII,25patientswithactiveB19infection(B19-specificIgM antibodies and/or plasma viremia); group III, 19 patients with latent/persistent B19 infection (virus-specific sequences in peripheral blood leukocytes' DNA with or without B19-specific IgG antibodies), and group IV, 13 patients without infection markers. The RA(DAS28) group was divided into four subgroups similarly to the main group: group I, 35; group II, 31; group III, 19; and group IV, 12 patients. Disease-specific clinical values in both groups were analyzed employing EFA, and the RA(DAS28) group was additionally assessed using Disease Activity Score (DAS)28. Results: RA activitywashigherinpatientswhohad markersofB19infection.Thehighestactivity of RA in both study groups was in patients with latent/persistent infection. In the RA(DAS28) group, according to DAS28, the highest activity of RA was in patients with active B19 infection. Conclusions: Using EFA and DAS28, a correlation between the clinical activity of RA and B19 infectionwasconfirmed.ThesedatasuggestthatEFAisapplicableformedico-biologicalstudies.
Keywords: Human parvovirus B19; Rheumatoid arthritis; Exploratory factor analysis Human parvovirus B19; Rheumatoid arthritis; Exploratory factor analysis
MDPI and ACS Style

Kakurina, N.; Kadisa, A.; Lejnieks, A.; Mikazane, H.; Kozireva, S.; Murovska, M. Use of exploratory factor analysis to ascertain the correlation between the activities of rheumatoid arthritis and infection by human parvovirus B19. Medicina 2015, 51, 18-24.

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