Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever
Materials and methods: A total of 60 patients with FMF and 60 healthy age- and sex- matched controls were included in this study. The patients with acute infection, chronic metabolic and rheumatic diseases, use of drugs other than colchicine and smoking history were excluded. CRP, ESR, total cholesterol, triglycerides, LDL-C, and HDL-C levels of patients and the control group were measured. Atherogenic index (TG/HDL-C) was calculated.
Results: We found that the atherogenic index values of the patients were significantly higher than those of the control group. HDL-C levels were lower and ESR and TG levels were higher in patients. Total cholesterol, LDL-C and CRP levels did not differ significantly between the two groups. There was no significant difference in the values of total cholesterol, LDL-C, triglycerides (TG), HDL-C, and atherogenic indexes between the groups of patients with and without M694V mutation.
Conclusions: Elaboration of clinical models of inflammation-induced atherogenesis may further advance our knowledge of multiple inflammatory pathways implicated in atherogenesis and provide a useful tool for cardiovascular prevention. We believe that the atherogenic index also be used as a preliminary indication of accelerated atherosclerosis in FMF. However, large- scale prospective studies on this issue are needed.
Acay, A.; Ulu, M.S.; Ahsen, A.; Ozkececi, G.; Demir, K.; Ozuguz, U.; Yuksel, S.; Acarturk, G. Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever. Medicina 2014, 50, 329-333.
Acay A, Ulu MS, Ahsen A, Ozkececi G, Demir K, Ozuguz U, Yuksel S, Acarturk G. Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever. Medicina. 2014; 50(6):329-333.Chicago/Turabian Style
Acay, Akif; Ulu, Memnune S.; Ahsen, Ahmet; Ozkececi, Gulay; Demir, Kasim; Ozuguz, Ufuk; Yuksel, Seref; Acarturk, Gursel. 2014. "Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever." Medicina 50, no. 6: 329-333.