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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever

1
Department of Internal Medicine, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
2
Department of Nephrology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
3
Department of Cardiology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
4
Department of Endocrinology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
5
Department of Gastroenterology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
*
Author to whom correspondence should be addressed.
Medicina 2014, 50(6), 329-333; https://doi.org/10.1016/j.medici.2014.11.009
Received: 9 April 2014 / Accepted: 10 November 2014 / Published: 28 November 2014
Background and objective: Numerous inflammatory and innate immune pathways are involved in atherogenesis. We aimed to investigate the atherogenic index and other lipid parameters in individuals with familial Mediterranean fever (FMF), as a predictor of atherosclerosis.
Materials and methods: A total of 60 patients with FMF and 60 healthy age- and sex- matched controls were included in this study. The patients with acute infection, chronic metabolic and rheumatic diseases, use of drugs other than colchicine and smoking history were excluded. CRP, ESR, total cholesterol, triglycerides, LDL-C, and HDL-C levels of patients and the control group were measured. Atherogenic index (TG/HDL-C) was calculated.
Results: We found that the atherogenic index values of the patients were significantly higher than those of the control group. HDL-C levels were lower and ESR and TG levels were higher in patients. Total cholesterol, LDL-C and CRP levels did not differ significantly between the two groups. There was no significant difference in the values of total cholesterol, LDL-C, triglycerides (TG), HDL-C, and atherogenic indexes between the groups of patients with and without M694V mutation.
Conclusions: Elaboration of clinical models of inflammation-induced atherogenesis may further advance our knowledge of multiple inflammatory pathways implicated in atherogenesis and provide a useful tool for cardiovascular prevention. We believe that the atherogenic index also be used as a preliminary indication of accelerated atherosclerosis in FMF. However, large- scale prospective studies on this issue are needed.
Keywords: Familial Mediterranean fever; Inflammation; Atherogenic index; Atherosclerosis Familial Mediterranean fever; Inflammation; Atherogenic index; Atherosclerosis
MDPI and ACS Style

Acay, A.; Ulu, M.S.; Ahsen, A.; Ozkececi, G.; Demir, K.; Ozuguz, U.; Yuksel, S.; Acarturk, G. Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever. Medicina 2014, 50, 329-333.

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