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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Relationship between ACTN3 R577X polymorphism and maximal power output in elite Polish athletes

Department of Nutrition Physiology, Institute of Sport, Warsaw, Poland
Department of Biomechanics, Institute of Sport, Warsaw, Poland
Institute of Physical Culture, Kazimierz Wielki University, Bydgoszcz, Poland
Department of Statistics, Józef Piłsudski University of Physical Education in Warsaw, Poland
Department of Physiology, Institute of Sport, Warsaw, Poland
Department of Anti-Doping Research, Institute of Sport, Warsaw, Poland
Author to whom correspondence should be addressed.
Medicina 2014, 50(5), 303-308;
Received: 16 January 2014 / Accepted: 7 August 2014 / Published: 29 October 2014
Background and objective: The main purpose of this study was to examine the association between ACTN3 R577X polymorphism and the ability to produce peak power in young male athletes from various sports. Our hypothesis was that the ACTN3 R577X polymorphism is associated with jumping performance and athletes with RR genotype have better scores in tests than athletes with XX or RX genotype independently of the sport discipline.
Materials and methods: Two hundred young Polish male participants representing different disciplines were recruited for this study. Genotyping for ACTN3 gene was performed using polymerase chain reaction. The power output of lower extremities and the height of rise of the body mass center during vertical jumps were measured on a force plate.
Results: The genotype distribution of the ACTN3 gene did not differ significantly between groups of athletes. The significant difference in height of counter-movement jump was found between athletes with RR and XX genotype (0.446 ± 0.049 m vs. 0.421 ± 0.036 m, respectively, P = 0.026). The ACTN3 RR genotype was associated with greater muscle power and height of jump in young male athletes.
Conclusions: These results suggest that the ACTN3 gene may play a significant role in determining muscle phenotypes. However, this gene is only one of many factors which could contribute to athletes' performance and muscle phenotypes.
Keywords: Athletes; Counter-movement jump; ACTN3 gene Athletes; Counter-movement jump; ACTN3 gene
MDPI and ACS Style

Orysiak, J.; Busko, K.; Michalski, R.; Mazur-Różycka, J.; Gajewski, J.; Malczewska-Lenczowska, J.; Sitkowski, D.; Pokrywka, A. Relationship between ACTN3 R577X polymorphism and maximal power output in elite Polish athletes. Medicina 2014, 50, 303-308.

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