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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers

1
Section of Anaesthesiology and Intensive Care, Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden
2
Institute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
3
Department of Electronics Engineering, Kaunas University of Technology, Kaunas, Lithuania
4
Clinic of Anaesthesiology and Intensive Care, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2014, 50(5), 255-262; https://doi.org/10.1016/j.medici.2014.09.007
Received: 11 April 2014 / Accepted: 7 August 2014 / Published: 1 October 2014
Background and objective: A mini volume loading test (mVLT) was proposed for estimating hydration status and interstitial fluid accumulation during stepwise infusion of crystalloids. The method is based on both the transcapillary reflux model and the hypothesis that when subjects are dehydrated, venous plasma dilution induced by a fluid challenge is higher than in the capillaries, and that difference is diminished when the fluid challenge is given to more hydrated individuals. Our objective was to test that hypothesis by evaluating the venocapillary dilution difference during mVLT in subjects with different hydration status.
Materials and methods: In a prospective randomized crossover study, three mini fluid challenges were given to 12 healthy volunteers on two occasions. The subjects were either dehydrated or hydrated before the experiments.
Results: In dehydrated subjects only, capillary plasma dilution was significantly lower than venous (P = 0.015, 0.005 and 0.006) after each mini fluid challenge.
Conclusions: Veno-capillary dilution difference during mVLT depends on the hydration status. The mVLT method could possibly discriminate between the different states of hydration.
Keywords: Noninvasive hemoglobin; Hydration status; Crystalloid; Interstitial fluid; Mini volume loading test Noninvasive hemoglobin; Hydration status; Crystalloid; Interstitial fluid; Mini volume loading test
MDPI and ACS Style

Svensen, C.H.; Stankevičius, E.; Broms, J.; Markevičius, V.; Andrijauskas, A. Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers. Medicina 2014, 50, 255-262.

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