Next Article in Journal
Nevomelanocytic atypia detection by in vivo reflectance confocal microscopy
Previous Article in Journal
Guidelines for diagnostics and treatment of aromatase inhibitor-induced bone loss in women with breast cancer A consensus of Lithuanian medical oncologists, radiation oncologists, endocrinologists, and family medicine physicians
Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Significance of blood serum catalase activity and malondialdehyde level for survival prognosis of ovarian cancer patients

1
Scientific Research Centre, National Cancer Institute, Vilnius, Lithuania
2
Faculty of Medicine, Vilnius University, Vilnius, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2014, 50(4), 204-208; https://doi.org/10.1016/j.medici.2014.09.001
Received: 24 April 2014 / Accepted: 18 September 2014 / Published: 30 September 2014
Background and objective: Several markers were found to be potential prognostic factors in ovarian cancer. Among markers resembling systemic changes in the host's organism are markers of the oxidative stress. In this study we attempted to analyze the oxidant and antioxidant parameters of ovarian cancer patients.
Materials and methods: A total of 42 patients with newly diagnosed stages I–IV primary ovary cancer were examined. Level of malondialdehyde (MDA) and catalytic activity catalase (CAT) were determined spectrophotometrically.
Results: Significantly lower CAT (28.2 ± 15.5 vs. 36.1 ± 14.6 nmol/L/min, P = 0.019) activity and higher MDA levels (8.7 ± 3.0 vs. 6.7 ± 2.7 nmol/L, P = 0.002) were observed in cancer patients compared with healthy volunteers. Both variables were not confirmed as prognostic factors according to Kaplan–Meier survival estimates.
Conclusions: MDA and CAT demonstrate oxidative stress in cancer patients: CAT activity was significantly lower and MDA levels higher in cancer patients compared to healthy controls. These variables were not confirmed to be prognostic factors in ovarian cancer, possibly due to small size of the study group.
Keywords: Ovarian cancer; Oxidative stress; Malondialdehyde; Catalase; Survival Ovarian cancer; Oxidative stress; Malondialdehyde; Catalase; Survival
MDPI and ACS Style

Didžiapetrienė, J.; Bublevič, J.; Smailytė, G.; Kazbarienė, B.; Stukas, R. Significance of blood serum catalase activity and malondialdehyde level for survival prognosis of ovarian cancer patients. Medicina 2014, 50, 204-208.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop