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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Reirradiation for patients with recurrence head and neck squamous cell carcinoma: A single-institution comparative study

1
Institute of Oncology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
2
Department of Otorhinolaryngology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
3
Department of Electronics Engineering, Kaunas University of Technology, Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2014, 50(2), 92-99; https://doi.org/10.1016/j.medici.2014.06.006
Received: 19 November 2013 / Accepted: 27 March 2014 / Published: 28 June 2014
Background and objective: In the last decade, the number of publications that report on the use of external beam radiotherapy and high-dose-rate brachytherapy (HDR-BRT) in the treat- ment of recurrent head and neck cancer has increased, but no studies compare external beam radiotherapy and HDR-BRT. The aim of this study was to evaluate and to compare the efficacy and toxicity of the three-dimensional conformal radiotherapy (3D-CRT) and HDRBRT in the treatment of recurrent head and neck cancer.
Material and methods: A total of 64 patients with head and neck cancer recurrence were randomly assigned at a 1:1 ratio to receive either 3D-CRT (50 Gy/25 fractions) in the control group or HDR-BRT (30 Gy/12 fraction) in the experimental group.
Results: The overall survival rate of patients treated with HDR-BRT at 1 and 2-years was 74% and 67%, respectively, compare to 3D-CRT group – 51% and 32%, respectively (P = 0.002). Local control at 1- and 2-years in patients who received HDR-BRT was 77% and 63% compare with 47% and 25%, respectively, for the patients who received the 3D-CRT (P < 0.001). Most patients developed mild to moderate acute mucositis and dermatitis. In the 3D-CRT group, severe late toxicity was determined in 11 patients (35.5%), and in the HDR-BRT group, in 1 patient (3.1%) (P = 0.001). There was no grade 5 toxicity.
Keywords: Reirradiation; Head and neck cancer; Brachytherapy Reirradiation; Head and neck cancer; Brachytherapy
MDPI and ACS Style

Rudžianskas, V.; Inčiūra, A.; Vaitkus, S.; Padervinskis, E.; Rudžianskienė, M.; Kupčinskaitė-Noreikienė, R.; Saltonaitė, L.; Noreika, A.; Statnickaitė, A.; Juozaitytė, E. Reirradiation for patients with recurrence head and neck squamous cell carcinoma: A single-institution comparative study. Medicina 2014, 50, 92-99.

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