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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Inhibition of Dendritic L-Type Calcium Current by Memantine in Frog Tectum

1
Department of Physics, Mathematics and Biophysics, Medical Academy, Lithuanian University of Health Sciences
2
Laboratory of Neurophysiology, Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2013, 49(9), 64; https://doi.org/10.3390/medicina49090064
Received: 20 June 2013 / Accepted: 29 September 2013 / Published: 4 October 2013
The aim of the study was to explore the effects of memantine on responses elicited in the frog tectum by the bursts of spikes of moderate strength of a single retina ganglion cell and to gain an insight about the effect of memantine on the L-type Ca2+ current.
Material and Methods
. The experiments were performed in vivo on adult frogs (Rana temporaria). An individual retina ganglion cell (or its retinotectal fiber) was stimulated by current pulses delivered through a multichannel stimulating electrode positioned on the retina. Responses to the discharge of a single retinal ganglion cell were recorded in the tectum by an extracellular carbonfiber microelectrode positioned in the terminal arborization of the retinotectal fiber in the tectum layer F. The solution of memantine (1-amino-3,5-dimethyladamantane) hydrochloride (30 or 45 μM) was applied onto the surface of the tectum by perfusion at a rate of 0.4 mL/min.
Results
. Memantine (30–45 μM) largely inhibited the L-type Ca2+ channel-mediated slow negative wave and late discharges seen in the tectum responses without any effect on fast synaptic retinotectal transmission.
Conclusions. Our results suggest that the neuroprotective effect of memantine could arise not only through the inhibition of the NMDA receptor current but also through the suppression of the L-type Ca2+ current.
Keywords: frog tectum; dendritic L-type calcium current; memantine; Alzheimer’s disease frog tectum; dendritic L-type calcium current; memantine; Alzheimer’s disease
MDPI and ACS Style

Baginskas, A.; Kuras, A.; Grigaliūnas, A. Inhibition of Dendritic L-Type Calcium Current by Memantine in Frog Tectum. Medicina 2013, 49, 64.

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