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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Plasma Homocysteine, Folic Acid, and Vitamin B12 Levels in Patients With Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma, and Normotensive Glaucoma

1
Department of Ophthalmology, Faculty of Medicine, Dicle University
2
Eye Clinic, Ankara Numune Education and Research Hospital
3
Department of Ophthalmology, Batman State Hospital, Turkey
*
Author to whom correspondence should be addressed.
Medicina 2013, 49(5), 34; https://doi.org/10.3390/medicina49050034
Received: 7 November 2012 / Accepted: 30 May 2013 / Published: 4 June 2013
Objective. The aim of this study was to evaluate the levels of plasma homocysteine (Hcy), vitamin B12, and folic acid in patients with pseudoexfoliation glaucoma (PEXG), pseudoexfoliation syndrome (PEXS), PEXS plus normotensive glaucoma (NTG).
Material and Methods. In total, 24 patients with PEXG, 35 patients with PEXS, 18 patients with PEXS plus NTG, and 35 control subjects were enrolled into study. Their Hcy levels were measured by high performance liquid chromatography (HPLC); the levels of vitamin B12 and folic acid were measured by a competitive electrochemiluminescence immunoassay.
Results. Higher plasma Hcy levels and lower folic acid and vitamin B12 levels were found in all 3 patients’ groups compared with the control group (all P<0.001, expect for folic acid in the PEXG group, P=0.03). Although plasma Hcy levels in the PEXG and PEXS groups were similar, the PEXS plus NTG group had significantly higher Hcy levels compared with these groups (P=0.019 and P=0.032, respectively).
Conclusions. Our study showed that there was an association between hyperhomocysteinemia and PEXS either with or without glaucoma. The patients with PEXS plus NTG had higher plasma Hcy levels than the patients with PEXS or PEXG and the healthy controls. The treatment of hyperhomocysteinemia by taking low-cost vitamin B12 and folic acid preparations may prevent additional vascular problems.
Keywords: homocysteine; pseudoexfoliation; normotensive glaucoma; folic acid; vitamin B12 homocysteine; pseudoexfoliation; normotensive glaucoma; folic acid; vitamin B12
MDPI and ACS Style

Türkcü, F.M.; Köz, Ö.G.; Yarangümeli, A.; Öner, V.; Kural, G. Plasma Homocysteine, Folic Acid, and Vitamin B12 Levels in Patients With Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma, and Normotensive Glaucoma. Medicina 2013, 49, 34.

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