Next Article in Journal
Surgical Treatment of Ventricular Septal Defect Following Myocardial Infarction: A Case Report
Previous Article in Journal
Endoscopic Removal of the Osteochondroma of the Fibular Head
Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

A Comparative Electron Microscopic Study of Bone Repair After Internal Fracture, Osteotomy, and Perforation of Rat Tibia

1
Institute of Anatomy, Faculty of Medicine, University of Tartu, Estonia
2
Department of Anatomy, Tsurumi University School of Dental Medicine, Japan
*
Author to whom correspondence should be addressed.
Medicina 2013, 49(4), 31; https://doi.org/10.3390/medicina49040031
Received: 30 November 2010 / Accepted: 30 April 2013 / Published: 5 May 2013
Background and Objective. Although previous studies have provided new information on bone repair, there are still gaps in knowledge about resorptive and formative processes during bone repair at the electron microscopic level. The aim of this study was to compare bone repair after the internal fracture, osteotomy, and bicortical perforation of the tibia by means of electron microscopy.
Material and Methods. An electron microscopic study of bone repair after the internal fracture, osteotomy, and bicortical perforation of the tibia was performed on 72 male Wistar rats. Rats undergoing osteotomy and perforation were further subdivided into the control and immobilization subgroups. Bone repair was observed during the first posttraumatic weeks.
Results
. Although bone repair in general had similar bone healing stages in all the groups, the repair process depended on the mode and degree of injury thus being different in the experimental groups. After the internal fracture, indirect ossification was observed; after osteotomy, primary periosteal, secondary endosteal ossification was noted; and after perforation, primary endosteal, secondary periosteal ossification was documented. Immobilization had an inhibitory effect on bone repair.
Conclusions. The results of the present study gave new information at the electron microscopic level about intracellular changes and intercellular matrix synthesis during different types of posttraumatic bone repair and confirmed our previous reports on similar posttraumatic bone repair in histomorphometric and immunohistochemical studies.
Keywords: posttraumatic bone repair; electron microscopy; osteohistogenesis; osteotomy; perforation; tibia posttraumatic bone repair; electron microscopy; osteohistogenesis; osteotomy; perforation; tibia
MDPI and ACS Style

Hussar, P.; Hussar, Ü.; Kouji, I.; Sato, T. A Comparative Electron Microscopic Study of Bone Repair After Internal Fracture, Osteotomy, and Perforation of Rat Tibia. Medicina 2013, 49, 31.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop