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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Influences of Genetic Variation of Endothelin-1 Gene on Effects of 16-Week Combined Exercise on Clinical and Physical Parameters in Middle-Aged Women

1
Department of Leisure and Sports, Sahmyook University
2
College of Physical Education, Hanyang University
3
Department of Sports Science, Saugkyunkwan University, Republic of Korea
*
Author to whom correspondence should be addressed.
Medicina 2013, 49(4), 27; https://doi.org/10.3390/medicina49040027
Received: 20 April 2012 / Accepted: 24 March 2013 / Published: 29 March 2013
Background and Objective. In this study, we attempted to determine whether the C/T polymorphism of the ET-1 gene was significantly associated with changes in several clinical characteristics after the 16-week combined exercise program in overweight middle-aged women.
Material and Methods.
The C/T polymorphism of the ET-1 gene was assayed using polymerase chain reaction, i.e., the TaqI restriction fragment length polymorphism method.
Results. The genetic variation in the ET-1 gene showed a significant association with the serum LDL cholesterol level as well as several parameters of physical fitness, including muscular endurance and power of the participants (P<0.05). In addition, this genetic variation showed a significant association with changes in muscular strength of the participants after the 16-week combined exercise program (P<0.05).
Conclusions. Our data suggest that the C/T substitution on intron 4 of the ET-1 gene may be a useful genetic marker influencing muscular strength through a gene-exercise interaction and is associated with an interindividual difference of cardiovascular risk factors and parameters of physical fitness.
Keywords: combined exercise; endothelin-1; Korean population; physical fitness; women combined exercise; endothelin-1; Korean population; physical fitness; women
MDPI and ACS Style

Lee, J.; Jung, I.; Kim, J.; Park, Y.; Kang, B. Influences of Genetic Variation of Endothelin-1 Gene on Effects of 16-Week Combined Exercise on Clinical and Physical Parameters in Middle-Aged Women. Medicina 2013, 49, 27.

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