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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Relationship Between Oxidative Stress Parameters and Cystatin C Levels in Patients With Severe Preeclampsia

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Department of Anesthesiology and Reanimation, Faculty of Medicine, Harran University
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Department of Internal Medicine, Faculty of Medicine, Harran University
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Department of Gynecology and Obstetrics, Faculty of Medicine, Harran University
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Department of Biochemistry, Faculty of Medicine, Harran University, Turkey
*
Authors to whom correspondence should be addressed.
Medicina 2013, 49(3), 19; https://doi.org/10.3390/medicina49030019
Received: 27 July 2012 / Accepted: 28 February 2013 / Published: 5 March 2013
Background and Objective. Oxidative stress is believed to play a role in the development of preeclampsia (PE). It is known that an increased cystatin C level is also associated with PE. The aim of this study was to investigate the relationship between oxidative stress parameters and cystatin C levels in patients with severe PE.
Material and Methods
. Forty-four patients with severe PE and 40 healthy pregnant women were recruited for the study. All study subjects were divided into 2 groups: group 1 (n=44) consisted of patients with severe PE, and group 2 (n=40) included healthy pregnant subjects. Blood samples were obtained from all subjects in order to measure the cystatin C level, total antioxidant status, and total oxidant status. The oxidative stress index was calculated.
Results
. The group 1 had significantly higher cystatin C, total oxidant status, oxidative stress index levels and lower total antioxidant status level as compared with the group 2 (P=0.001, P<0.001, P<0.001, P=0.036, respectively). The serum cystatin C level was significantly correlated with the oxidative stress index (r=0.609, P<0.001).
Conclusions
. The present study demonstrated that both oxidative stress and cystatin C levels were increased in patients with PE, and the increased cystatin C levels seem to be a consequence of oxidative stress. Correspondence to
Keywords: preeclampsia; total antioxidant status; total oxidant status; oxidative stress index; cystatin C preeclampsia; total antioxidant status; total oxidant status; oxidative stress index; cystatin C
MDPI and ACS Style

Yalcin, S.; Ulas, T.; Eren, M.A.; Aydogan, H.; Camuzcuoglu, A.; Kucuk, A.; Yuce, H.H.; Demir, M.E.; Vural, M.; Aksoy, N. Relationship Between Oxidative Stress Parameters and Cystatin C Levels in Patients With Severe Preeclampsia. Medicina 2013, 49, 19.

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